Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2

doi:10.3390/vaccines8020293

. 2020 Jun 10;8(2):293.

doi: 10.3390/vaccines8020293.

Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2

Mariangela Garofalo¹, Monika Staniszewska², Stefano Salmaso¹, Paolo Caliceti¹, Katarzyna Wanda Pancer³, Magdalena Wieczorek³, Lukasz Kuryk^{3

4}

Affiliations

¹ Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
² Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.
³ Department of Virology, National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland.
⁴ Clinical Science, Targovax Oy, Saukonpaadenranta 2, 00180 Helsinki, Finland.

PMID: 32531955
PMCID: PMC7349996
DOI: 10.3390/vaccines8020293

Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2

Mariangela Garofalo et al. Vaccines (Basel). 2020.

. 2020 Jun 10;8(2):293.

doi: 10.3390/vaccines8020293.

Authors

Mariangela Garofalo¹, Monika Staniszewska², Stefano Salmaso¹, Paolo Caliceti¹, Katarzyna Wanda Pancer³, Magdalena Wieczorek³, Lukasz Kuryk^{3

4}

Affiliations

¹ Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
² Chair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.
³ Department of Virology, National Institute of Public Health-National Institute of Hygiene, Chocimska 24, 00-791 Warsaw, Poland.
⁴ Clinical Science, Targovax Oy, Saukonpaadenranta 2, 00180 Helsinki, Finland.

PMID: 32531955
PMCID: PMC7349996
DOI: 10.3390/vaccines8020293

Abstract

The current appearance of the new SARS coronavirus 2 (SARS-CoV-2) and it quickly spreading across the world poses a global health emergency. The serious outbreak position is affecting people worldwide and requires rapid measures to be taken by healthcare systems and governments. Vaccinations represent the most effective strategy to prevent the epidemic of the virus and to further reduce morbidity and mortality with long-lasting effects. Nevertheless, currently there are no licensed vaccines for the novel coronaviruses. Researchers and clinicians from all over the world are advancing the development of a vaccine against novel human SARS-CoV-2 using various approaches. Herein, we aim to present and discuss the progress and prospects in the field of vaccine research towards SARS-CoV-2 using adenovirus (AdV) replication deficient-based strategies, with a comprehension that may support research and combat this recent world health emergency.

Keywords: COVID-19; SARS-CoV-2; adenovirus; adjuvant; vaccine.

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Conflict of interest statement

L.K. is an employee in Targovax Oy in Finland. All the other authors declare no potential conflicts of interest.

Figures

**Figure 1**
Coronavirus disease 19 (COVID-19) treatments and vaccines in a research pipeline with a percentage distribution.

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[1] Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W., Si H.R., Zhu Y., Li B., Huang C.L., et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270–273. doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed

[2] Zhou P., Yang X.L., Wang X.G., Hu B., Zhang L., Zhang W., Si H.R., Zhu Y., Li B., Huang C.L., et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270–273. doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed

[3] Chan J.F.-W., Yuan S., Kok K.-H., To K.K.-W., Chu H., Yang J., Xing F., Liu J., Yip C.C.-Y., Poon R.W.-S., et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster. Lancet. 2020;395:514–523. doi: 10.1016/S0140-6736(20)30154-9. - DOI - PMC - PubMed

[4] Chan J.F.-W., Yuan S., Kok K.-H., To K.K.-W., Chu H., Yang J., Xing F., Liu J., Yip C.C.-Y., Poon R.W.-S., et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster. Lancet. 2020;395:514–523. doi: 10.1016/S0140-6736(20)30154-9. - DOI - PMC - PubMed

[5] Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., Wang W., Song H., Huang B., Zhu N., et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet. 2020;395:565–574. doi: 10.1016/S0140-6736(20)30251-8. - DOI - PMC - PubMed

[6] Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., Wang W., Song H., Huang B., Zhu N., et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet. 2020;395:565–574. doi: 10.1016/S0140-6736(20)30251-8. - DOI - PMC - PubMed

[7] Ronco C., Reis T., Husain-Syed F. Management of acute kidney injury in patients with COVID-19. Lancet Respir. Med. 2020 doi: 10.1016/S2213-2600(20)30229-0. - DOI - PMC - PubMed

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[9] Chu K.H., Tsang W.K., Tang C.S., Lam M.F., Lai F.M., To K.F., Fung K.S., Tang H.L., Yan W.W., Chan H.W., et al. Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Kidney Int. 2005;67:698–705. doi: 10.1111/j.1523-1755.2005.67130.x. - DOI - PMC - PubMed

[10] Chu K.H., Tsang W.K., Tang C.S., Lam M.F., Lai F.M., To K.F., Fung K.S., Tang H.L., Yan W.W., Chan H.W., et al. Acute renal impairment in coronavirus-associated severe acute respiratory syndrome. Kidney Int. 2005;67:698–705. doi: 10.1111/j.1523-1755.2005.67130.x. - DOI - PMC - PubMed

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Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2

Affiliations

Prospects of Replication-Deficient Adenovirus Based Vaccine Development against SARS-CoV-2

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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