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. 2020 Sep;137(4):291-296.
doi: 10.1016/j.anorl.2020.05.015. Epub 2020 May 31.

The influenza virus, SARS-CoV-2, and the airways: Clarification for the otorhinolaryngologist

L de Gabory  1 , A Alharbi  2 , M Kérimian  2 , M-E Lafon  3
Affiliations

The influenza virus, SARS-CoV-2, and the airways: Clarification for the otorhinolaryngologist

L de Gabory et al. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Sep.

Abstract

The influenza virus and SARS-CoV-2 cause trivial upper and severe lower respiratory infections (Influenza virus 290,000 to 650,000 deaths/year). These viruses come into contact with the airways either by direct projection, by secondary inhalation of airborne droplets, or by handling (fomites). The objective of this article is to clarify the mechanisms of production and penetration of droplets of secretions emitted during all expiratory phenomena likely to transport these viruses and come into contact with the respiratory mucosa. The droplets>5μm follow the laws of ballistics, those<5μm follow Brownian motion and remain suspended in the air. The aerosols of droplets are very heterogeneous whether the subject is healthy or sick. During an infectious period, not all droplets contain viral RNA. If these RNAs are detectable around patients, on surfaces, and in the ambient air at variable distances according to the studies (from 0.5m to beyond the patient's room), this is without prejudice to the infectious nature (viability) of the virus and the minimum infectious dose. There is a time lag between the patient's infectious period and that of RNA detection for both viruses. Subsequently, the inhaled particles must meet the laws of fluid dynamics (filtration) to settle in the respiratory tree. All of this partly explains the contagiousness and the clinical expression of these two viruses from the olfactory cleft to the alveoli.

Keywords: Airborne particle; COVID-19; Influenza virus; Respiratory infection; SARS-CoV-2.

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References

    1. Eccles R. Understanding the symptoms of the common cold and influenza. Lancet Infect Dis. 2005;5:718–725. - PMC - PubMed
    1. Zambon M.C., Stockton J.D., Clewley J.P., Fleming D.M. Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study. Lancet. 2001;358:1410–1416. - PubMed
    1. Coronaviridae Study Group of the International Committee on Taxonomy of Viruses The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020;5(4):536–544. - PMC - PubMed
    1. Song W., Gui M., Wang X., Xiang Y. Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. PLoS Pathog. 2018;14(8):e1007236. - PMC - PubMed
    1. Olender T., Keydar I., Pinto J.M., Tatarskyy P., Alkelai A., Chien M.S. The human olfactory transcriptome. BMC Genomics. 2016;17:619. - PMC - PubMed