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Review
. 2020:1195:249-254.
doi: 10.1007/978-3-030-32633-3_33.

The Misfolding of Proteins

Agathi Argyrou  1
Affiliations
Review

The Misfolding of Proteins

Agathi Argyrou. Adv Exp Med Biol. 2020.

Abstract

Protein folding is considered strongly linked with genetics. The deeper understanding of the mechanisms that allow the folding of proteins is expected to lead to advances in the pharmaceutical sector. The shape of a protein dictates its biological activity, and any exceptions from its natural form can lead to diseases such as Alzheimer's, Parkinson's, and many others. The recent advances in the research of protein folding include computational models for the prediction of protein folding with enough accuracy. In order to understand the process of protein misfolding, a synopsis of the properties of protein molecules is required.

Keywords: Aggregation; Chaperones; Misfolding proteins; Protein folding.

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