Insight toward the MicroRNA Profiling of Laryngeal Cancers: Biological Role and Clinical Impact

doi:10.3390/ijms21103693

Review

. 2020 May 24;21(10):3693.

doi: 10.3390/ijms21103693.

Insight toward the MicroRNA Profiling of Laryngeal Cancers: Biological Role and Clinical Impact

Takashi Takeuchi^{1

2}, Hiromichi Kawasaki^{1

3}, Amalia Luce¹, Alessia Maria Cossu^{1

4}, Gabriella Misso¹, Marianna Scrima⁴, Marco Bocchetti^{1

4}, Filippo Ricciardiello⁵, Michele Caraglia^{1

4}, Silvia Zappavigna¹

Affiliations

¹ Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
² Molecular Diagnostics Division, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 739-1195, Japan.
³ Drug Discovery Laboratory, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 739-1195, Japan.
⁴ Biogem Scarl, Institute of Genetic Research, Laboratory of Molecular and Precision Oncology, 83031 Ariano Irpino, Italy.
⁵ Division of Otorhinolaryngology, "A. Cardarelli" Hospital, 80131 Naples, Italy.

PMID: 32456271
PMCID: PMC7279294
DOI: 10.3390/ijms21103693

Review

Insight toward the MicroRNA Profiling of Laryngeal Cancers: Biological Role and Clinical Impact

Takashi Takeuchi et al. Int J Mol Sci. 2020.

. 2020 May 24;21(10):3693.

doi: 10.3390/ijms21103693.

Authors

Affiliations

¹ Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
² Molecular Diagnostics Division, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 739-1195, Japan.
³ Drug Discovery Laboratory, Wakunaga Pharmaceutical Co., Ltd., Hiroshima 739-1195, Japan.
⁴ Biogem Scarl, Institute of Genetic Research, Laboratory of Molecular and Precision Oncology, 83031 Ariano Irpino, Italy.
⁵ Division of Otorhinolaryngology, "A. Cardarelli" Hospital, 80131 Naples, Italy.

PMID: 32456271
PMCID: PMC7279294
DOI: 10.3390/ijms21103693

Abstract

Head and neck squamous cell carcinoma (HNSCC), a heterogeneous disease arising from various anatomical locations including the larynx, is a leading cause of death worldwide. Despite advances in multimodality treatment, the overall survival rate of the disease is still largely dismal. Early and accurate diagnosis of HNSCC is urgently demanded in order to prevent cancer progression and to improve the quality of the patient's life. Recently, microRNAs (miRNAs), a family of small non-coding RNAs, have been widely reported as new robust tools for prediction, diagnosis, prognosis, and therapeutic approaches of human diseases. Abnormally expressed miRNAs are strongly associated with cancer development, resistance to chemo-/radiotherapy, and metastatic potential through targeting a large variety of genes. In this review, we summarize on the recent reports that emphasize the pivotal biological roles of miRNAs in regulating carcinogenesis of HNSCC, particularly laryngeal cancer. In more detail, we report the characterized miRNAs with an evident either oncogenic or tumor suppressive role in the cancers. In addition, we also focus on the correlation between miRNA deregulation and clinical relevance in cancer patients. On the basis of intriguing findings, the study of miRNAs will provide a new great opportunity to access better clinical management of the malignancies.

Keywords: biomarkers; chemo-/radio resistance; head and neck cancer; laryngeal cancer; lifestyle habit; metastasis; microRNA; prediction; prognosis; therapeutic target.

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Conflict of interest statement

All the authors declared no conflict of interest.

Figures

**Figure 1**
MiRNA biogenesis. miRNA gene is transcribed to generate a primary miRNA (pri-miRNA) precursor molecule that undergoes nuclear cleavage to form a second precursor miRNA (pre-miRNA). The pre-miRNA is exported in the cytoplasm and cleaved to generate a microRNA duplex containing the mature miRNA. The duplex unwinds and the mature miRNA assembles into RISC. The miRNA base-pairs with target mRNA to perform gene silencing trough mRNA cleavage or translation repression.

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References

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1. Kulasinghe A., Perry C., Jovanović L., Nelson C., Punyadeera C. Circulating tumour cells in metastatic head and neck cancers. Int. J. Cancer. 2014;136:2515–2523. doi: 10.1002/ijc.29108. - DOI - PubMed
1. Babu J.M., Prathibha R., Jijith V., Hariharan R., Pillai M.R. A miR-centric view of head and neck cancers. Biochim. Biophys. Acta Rev. Cancer. 2011;1816:67–72. doi: 10.1016/j.bbcan.2011.04.003. - DOI - PubMed
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[1] Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., Thun M.J. Cancer statistics, 2008. CA Cancer J. Clin. 2008;58:71–96. doi: 10.3322/CA.2007.0010. - DOI - PubMed

[2] Jemal A., Siegel R., Ward E., Hao Y., Xu J., Murray T., Thun M.J. Cancer statistics, 2008. CA Cancer J. Clin. 2008;58:71–96. doi: 10.3322/CA.2007.0010. - DOI - PubMed

[3] Leemans C.R., Braakhuis B.J.M., Brakenhoff R.H. Response to correspondence on the molecular biology of head and neck cancer. Nat. Rev. Cancer. 2011;11:382. doi: 10.1038/nrc2982-c2. - DOI - PubMed

[4] Leemans C.R., Braakhuis B.J.M., Brakenhoff R.H. Response to correspondence on the molecular biology of head and neck cancer. Nat. Rev. Cancer. 2011;11:382. doi: 10.1038/nrc2982-c2. - DOI - PubMed

[5] Kulasinghe A., Perry C., Jovanović L., Nelson C., Punyadeera C. Circulating tumour cells in metastatic head and neck cancers. Int. J. Cancer. 2014;136:2515–2523. doi: 10.1002/ijc.29108. - DOI - PubMed

[6] Kulasinghe A., Perry C., Jovanović L., Nelson C., Punyadeera C. Circulating tumour cells in metastatic head and neck cancers. Int. J. Cancer. 2014;136:2515–2523. doi: 10.1002/ijc.29108. - DOI - PubMed

[7] Babu J.M., Prathibha R., Jijith V., Hariharan R., Pillai M.R. A miR-centric view of head and neck cancers. Biochim. Biophys. Acta Rev. Cancer. 2011;1816:67–72. doi: 10.1016/j.bbcan.2011.04.003. - DOI - PubMed

[8] Babu J.M., Prathibha R., Jijith V., Hariharan R., Pillai M.R. A miR-centric view of head and neck cancers. Biochim. Biophys. Acta Rev. Cancer. 2011;1816:67–72. doi: 10.1016/j.bbcan.2011.04.003. - DOI - PubMed

[9] Janiszewska J., Szaumkessel M., Szyfter-Harris J. MicroRNAs are important players in head and neck carcinoma: A review. Crit. Rev. Oncol. 2013;88:716–728. doi: 10.1016/j.critrevonc.2013.07.012. - DOI - PubMed

[10] Janiszewska J., Szaumkessel M., Szyfter-Harris J. MicroRNAs are important players in head and neck carcinoma: A review. Crit. Rev. Oncol. 2013;88:716–728. doi: 10.1016/j.critrevonc.2013.07.012. - DOI - PubMed

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Insight toward the MicroRNA Profiling of Laryngeal Cancers: Biological Role and Clinical Impact

Affiliations

Insight toward the MicroRNA Profiling of Laryngeal Cancers: Biological Role and Clinical Impact

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