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Meta-Analysis
. 2020 May 18;12(10):9380-9404.
doi: 10.18632/aging.103214. Epub 2020 May 18.

Prognostic value of microRNAs in pancreatic cancer: a meta-analysis

Fei Zhao  1 , Chao Wei  2 , Meng-Ying Cui  3 , Qiang-Qiang Xia  4 , Shuai-Bin Wang  5 , Yue Zhang  6   7
Affiliations
Meta-Analysis

Prognostic value of microRNAs in pancreatic cancer: a meta-analysis

Fei Zhao et al. Aging (Albany NY). .

Abstract

Background: The prognostic impact of microRNA (miRNA) expression levels in pancreatic cancer (PC) has been estimated for years, but the outcomes are controversial and heterogeneous. Therefore, we comprehensively reviewed the evidence collected on miRNA expression in PC to determine this effect.

Results: PC patients with high miR-21 (HR=2.61, 95%CI=1.68-4.04), miR-451a (HR=2.23, 95%CI=1.23-4.04) or miR-1290 (HR=1.43, 95%CI=1.04-1.95) levels in blood had significantly poorer OS (P<0.05). Furthermore, PC patients with high miR-10b (HR=1.73, 95%CI=1.09-2.76), miR-17-5p (HR=1.91, 95%CI=1.30-2.80), miR-21 (HR=1.90, 95%CI=1.61-2.25), miR-23a (HR=2.18, 95%CI=1.52-3.13), miR-155 (HR=2.22, 95%CI=1.27-3.88), miR-203 (HR=1.65, 95%CI=1.14-2.40), miR-221 (HR=1.72, 95%CI=1.08-2.74), miR-222 levels (HR=1.72, 95%CI=1.02-2.91) or low miR-29c (HR=1.39, 95%CI=1.08-1.79), miR-126 (HR=1.55, 95%CI=1.23-1.95), miR-218 (HR=2.62, 95%CI=1.41-4.88) levels in tissues had significantly shorter OS (P<0.05).

Conclusions: In summary, blood miR-21, miR-451a, miR-1290 and tissue miR-10b, miR-17-5p, miR-21, miR-23a, miR-29c, miR-126, miR-155, miR-203, miR-218, miR-221, miR-222 had significant prognostic value.

Methods: We searched PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews to recognize eligible studies, and 57 studies comprising 5445 PC patients and 15 miRNAs were included to evaluate the associations between miRNA expression levels and overall survival (OS) up to June 1, 2019. Summary hazard ratios (HR) with 95% confidence intervals (CI) were calculated to assess the effect.

Keywords: meta-analysis; microRNA; pancreatic cancer; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Forest plot about OS of PC patients with high miR-21, miR-196a, miR-451a or miR-1290 level in blood
Figure 2
Figure 2
Forest plot about OS of PC patients with high miR-10b, miR-17-5P or miR-21 level in tissue.
Figure 3
Figure 3
Forest plot about OS of PC patients with high miR-21 level in tissue (multivariate analysis).
Figure 4
Figure 4
Begg’s funnel plot about OS of PC patients with high miR-21 level in tissue.
Figure 5
Figure 5
Sensitivity analysis about OS of PC patients with high miR-21 level in tissue.
Figure 6
Figure 6
Funnel plot about pooled analysis adjusted with trim and fill method of OS of PC patients with high miR-21 level in tissue. Circles: included studies; diamonds: presumed missing studies.
Figure 7
Figure 7
Forest plot about OS of PC patients with high miR-23a, miR-155, miR-203, miR-221, miR-222 or low miR-29c, miR-126, miR-200c, miR-218 level in tissue.
Figure 8
Figure 8
Flow diagram of literature search and selection.
See this image and copyright information in PMC

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