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Comment
. 2020 May 14:9:e56886.
doi: 10.7554/eLife.56886.

Untangling the immune basis of disease susceptibility

Ruy M Ribeiro  1 , Luis Graca  2
Affiliations
Comment

Untangling the immune basis of disease susceptibility

Ruy M Ribeiro et al. Elife. .

Abstract

Interactions between immune cell receptors and proteins that determine disease susceptibility shed light on how different arms of the immune system are involved in three viral infections and Crohn's disease.

Keywords: CD8 T cell; GWAS; HLA; computational biology; disease association; human; immunogenetics; immunology; inflammation; natural killer cell; systems biology.

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Conflict of interest statement

RR, LG No competing interests declared

Figures

Figure 1.
Figure 1.. Axes of similarity in MHC proteins.
Debebe et al. showed that similarities in regions of the MHC molecule that interact with different immune cell receptors can be thought of in terms of different 'spaces' (which are defined by an axis for each type of receptor). They found that MHCs that are similar in the T-cell receptor (TCR) axis are associated with disease outcomes for HLTV-1, hepatitis C virus (HCV) and HIV-1. Disease outcomes for HIV-1 are also associated with MHCs that show similarity in the killer immunoglobulin-like receptor (KIR) axis. For the diseases tested, no MHCs were found to be similar in the region that interacts with the leukocyte immunoglobulin-like receptor (LILR) carried by myeloid cells (MC). CD8: CD8+ T cells; NK: natural killer cells; blue circle: peptide.
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