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Review
. 2020 Jun:52:9-17.
doi: 10.1016/j.coph.2020.03.006. Epub 2020 May 7.

Gut microbiota and regulation of myokine-adipokine function

Francesco Suriano  1 , Matthias Van Hul  1 , Patrice D Cani  2
Affiliations
Free article
Review

Gut microbiota and regulation of myokine-adipokine function

Francesco Suriano et al. Curr Opin Pharmacol. 2020 Jun.
Free article

Abstract

Both skeletal muscle and adipose tissue are considered as endocrine organs due to their ability to produce and secrete several bioactive peptides (e.g. myokines and adipokines). Those bioactive molecules are well known for their capacity to influence whole-body homeostasis and alterations in their production/secretion are contributing to the development of various metabolic disorders. While it is well accepted that changes in the composition and functionality of the gut microbiota are associated with the onset of several pathological disorders (e.g. obesity, diabetes, and cancer), its contribution to the regulation of the myokine-adipokine profile and function remains largely unknown. This review will focus on myokines and adipokines with a special interest on their interaction with the gut microbiota.

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