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Review
. 2020 Jul;9(13):4736-4742.
doi: 10.1002/cam4.3067. Epub 2020 May 5.

The neonatal Fc receptor in cancer FcRn in cancer

Diana Cadena Castaneda  1 , Guillaume Brachet  1   2 , Caroline Goupille  2   3 , Lobna Ouldamer  2   3 , Valérie Gouilleux-Gruart  1   2
Affiliations
Review

The neonatal Fc receptor in cancer FcRn in cancer

Diana Cadena Castaneda et al. Cancer Med. 2020 Jul.

Abstract

Since the neonatal IgG Fc receptor (FcRn) was discovered, it was found to be involved in immunoglobulin recycling and biodistribution, immune complexes routing, antigen presentation, humoral immune response, and cancer immunosurveillance. The latest data show that FcRn plays a part in cancer pathophysiology. In various types of cancers, such as lung and colorectal cancer, FcRn has been described as an early marker for prognosis. Dysregulation of FcRn expression by cancer cells allows them to increase their metabolism, and this process could be exploited for passive targeting of cytotoxic drugs. However, the roles of this receptor depend on whether the studied cell population is the tumor tissue or the infiltrating cells, bringing forward the need for further studies.

Keywords: FCGRT; Neonatal Fc receptor; antigen presentation; cancer; cancer prognosis; cross-presentation; immune complexes; immunosurveillance; tumor metabolism.

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Figures

FIGURE 1
FIGURE 1
Documented mechanistic insights into the role of the neonatal Fc receptor in cancer immunosurveillance (left panel) and the effects of its dysregulation on tumor growth and metastasis (right), either in the case of overexpression (bottom) or underexpression (top). The inset at the right side describes the expected mechanism of action of albumin‐drug conjugates on cancer cells that underexpress FcRn. Albumin is pinocytosed, and directed to endosomes. In the absence of the neonatal Fc receptor, it is digested instead of being recycled back to the membrane. Treatment with albumin‐drug conjugates leads to the catabolism of the protein moiety and cellular accumulation of the cytotoxic drug. LB and LT stand for B‐ and T‐lymphocytes respectively. Albumin is represented as orange triangles, cytotoxic drug moiety is depicted as bombs, and nutrients as a ball with two side chains, also in black
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References

    1. Brambell FW, Hemmings WA, Morris IG. A theoretical model of gamma‐globulin catabolism. Nature. 1964;203:1352. - PubMed
    1. Brambell FW. The transmission of immune globulins from the mother to the foetal and newborn young. Proc Nutr Soc. 1969;28:35‐41. - PubMed
    1. Chaudhury C, Brooks CL, Carter DC, Robinson JM, Anderson CL. Albumin binding to FcRn: distinct from the FcRn‐IgG interaction. Biochemistry. 2006;45:4983‐4990. - PubMed
    1. Oganesyan V, Damschroder MM, Cook KE et al Structural insights into neonatal Fc receptor‐based recycling mechanisms. J Biol Chem. 2014;289:7812‐7824. - PMC - PubMed
    1. Abdiche YN, Yeung YA, Chaparro‐Riggers J et al The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity. mAbs. 2015;7:331‐343. - PMC - PubMed

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