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Review
. 2020 May 4;147(9):dev188573.
doi: 10.1242/dev.188573.

Once upon a dish: engineering multicellular systems

Kristina Haase  1 , Benjamin S Freedman  2
Affiliations
Review

Once upon a dish: engineering multicellular systems

Kristina Haase et al. Development. .

Abstract

In February 2020, the European Molecular Biology Laboratory (EMBL) and the Institute for Bioengineering of Catalonia (IBEC) joined forces to unite researchers from all over the globe to discuss emerging topics in 'Engineering Multicellular Systems'. As we review here, key themes that arose throughout the meeting included the ethics of organoids in developmental biology, bottom-up versus top-down models, tissue organizing principles, and the future of improving these systems to better mimic the natural world.

Keywords: Embryoids; Morphogenesis; Organ-on-chip; Patterning; Signaling; Synthetic embryos; Vascularization.

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Conflict of interest statement

Competing interestsDr Freedman is an inventor on patent applications related to kidney organoids and is an advisor for Chinook Therapeutics. The authors declare no other competing or financial interests.

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