Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Apr 27;9(5):1266.
doi: 10.3390/jcm9051266.

Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement

Anna Di Lorenzo  1 , Gabriella Iannuzzo  2 , Alessandro Parlato  1 , Gianluigi Cuomo  1 , Crescenzo Testa  1 , Marta Coppola  1 , Giuseppe D'Ambrosio  1 , Domenico Alessandro Oliviero  1 , Silvia Sarullo  3 , Giuseppe Vitale  3 , Cinzia Nugara  3 , Filippo M Sarullo  3 , Francesco Giallauria  1
Affiliations
Review

Clinical Evidence for Q10 Coenzyme Supplementation in Heart Failure: From Energetics to Functional Improvement

Anna Di Lorenzo et al. J Clin Med. .

Abstract

Oxidative stress and mitochondrial dysfunction are hallmarks of heart failure (HF). Coenzyme Q10 (CoQ10) is a vitamin-like organic compound widely expressed in humans as ubiquinol (reduced form) and ubiquinone (oxidized form). CoQ10 plays a key role in electron transport in oxidative phosphorylation of mitochondria. CoQ10 acts as a potent antioxidant, membrane stabilizer and cofactor in the production of adenosine triphosphate by oxidative phosphorylation, inhibiting the oxidation of proteins and DNA. Patients with HF showed CoQ10 deficiency; therefore, a number of clinical trials investigating the effects of CoQ10 supplementation in HF have been conducted. CoQ10 supplementation may confer potential prognostic advantages in HF patients with no adverse hemodynamic profile or safety issues. The latest evidence on the clinical effects of CoQ10 supplementation in HF was reviewed.

Keywords: coenzyme Q10; coenzyme Q10 deficiency; coenzyme Q10 supplementation; heart failure; heart failure mortality.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Pathophysiological mechanisms and potential clinical benefits of CoQ10 in heart failure. LV Left: Ventricle; MACE: Major Adverse Cardiovascular Events; MMP: Matrix Metalloproteinase; NAD(P)H: Nicotinamide adenine dinucleotide phosphate; NFkB: nuclear factor kappa-light-chain-enhancer of activated B cells; NO: Nitric Oxyde; QoL: Quality of Life; ROS: Reactive Oxygen Species.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Dunlay S.M., Pereira N.L., Kushwaha S.S. Contemporary strategies in the diagnosis and management of heart failure. Mayo Clin. Proc. 2014;89:662–676. doi: 10.1016/j.mayocp.2014.01.004. - DOI - PMC - PubMed
    1. Giallauria F., Vigorito C., Piepoli M.F., Coats A.J.S. Effects of cardiac contractility modulation by non-excitatory electrical stimulation on exercise capacity and quality of life: An individual patient’s data meta-analysis of randomized controlled trials. Int. J. Cardiol. 2014;175:352–357. doi: 10.1016/j.ijcard.2014.06.005. - DOI - PubMed
    1. Mahmood S.S., Wang T.J. The Epidemiology of Congestive Heart Failure: Contributions from the Framingham Heart Study. Glob. Hear. 2013;8:77–82. doi: 10.1016/j.gheart.2012.12.006. - DOI - PMC - PubMed
    1. Aimo A., Castiglione V., Borrelli C., Saccaro L.F., Franzini M., Masi S., Emdin M., Giannoni A. Oxidative stress and inflammation in the evolution of heart failure: From pathophysiology to therapeutic strategies. Eur. J. Prev. Cardiol. 2019;27:494–510. doi: 10.1177/2047487319870344. - DOI - PubMed
    1. Kumar A.A., Kelly D.P., Chirinos J.A. Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction. Circulation. 2019;139:1435–1450. doi: 10.1161/CIRCULATIONAHA.118.036259. - DOI - PMC - PubMed