Should we try the antiinflammatory natural product, celastrol, for COVID-19?

doi:10.1002/ptr.6711

Comment

. 2020 Jun;34(6):1189-1190.

doi: 10.1002/ptr.6711. Epub 2020 Apr 29.

Should we try the antiinflammatory natural product, celastrol, for COVID-19?

Solomon Habtemariam¹, Seyed Fazel Nabavi², Ioana Berindan-Neagoe^{3

4

5}, Cosmin Andrei Cismaru^{3

6}, Morteza Izadi², Antoni Sureda⁷, Seyed Mohammad Nabavi²

Affiliations

¹ Pharmacognosy Research Laboratories and Herbal Analysis Services, University of Greenwich, Kent, UK.
² Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran.
³ Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
⁴ Research Center for Advanced Medicine - Medfuture, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
⁵ The Functional Genomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.
⁶ Department of Functional Sciences, Immunology and Allergology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
⁷ Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, Health Research Institute of Balearic Islands (IdISBa), and CIBEROBN (Physiopathology of Obesity and Nutrition), Palma, Spain.

PMID: 32347602
PMCID: PMC7267639
DOI: 10.1002/ptr.6711

Comment

Should we try the antiinflammatory natural product, celastrol, for COVID-19?

Solomon Habtemariam et al. Phytother Res. 2020 Jun.

. 2020 Jun;34(6):1189-1190.

doi: 10.1002/ptr.6711. Epub 2020 Apr 29.

Authors

Solomon Habtemariam¹, Seyed Fazel Nabavi², Ioana Berindan-Neagoe^{3

4

5}, Cosmin Andrei Cismaru^{3

6}, Morteza Izadi², Antoni Sureda⁷, Seyed Mohammad Nabavi²

Affiliations

¹ Pharmacognosy Research Laboratories and Herbal Analysis Services, University of Greenwich, Kent, UK.
² Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran.
³ Research Center for Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
⁴ Research Center for Advanced Medicine - Medfuture, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
⁵ The Functional Genomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.
⁶ Department of Functional Sciences, Immunology and Allergology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
⁷ Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, Health Research Institute of Balearic Islands (IdISBa), and CIBEROBN (Physiopathology of Obesity and Nutrition), Palma, Spain.

PMID: 32347602
PMCID: PMC7267639
DOI: 10.1002/ptr.6711

No abstract available

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Conflict of interest statement

The authors declare that there is no conflict of interest.

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References

1. Bugge, T. H. , Antalis, T. M. , & Wu, Q. (2009). Type II transmembrane serine proteases. Journal of Biological Chemistry, 284(35), 23177–23181. - PMC - PubMed
1. Fan, H. H. , Wang, L. Q. , Liu, W. L. , An, X. P. , Liu, Z. D. , He, X. Q. , … Tong, Y. G. (2020). Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019‐novel coronavirus (2019‐nCoV) related coronavirus model. Chinese Medical Journal, 1. 10.1097/CM9.0000000000000797 - DOI - PMC - PubMed
1. Han, L. P. , Sun, B. , Li, C. J. , Xie, Y. , & Chen, L. M. (2018). Effect of celastrol on toll‐like receptor 4‐mediated inflammatory response in free fatty acid‐induced HepG2 cells. International Journal of Molecular Medicine, 42(4), 2053–2061. - PMC - PubMed
1. Heinrich, M. , Appendino, G. , Efferth, T. , Fürst, R. , Izzo, A. A. , Kayser, O. , … Viljoen, A. (2020). Best practice in research–overcoming common challenges in phytopharmacological research. Journal of Ethnopharmacology, 246, 112230. 10.1016/j.jep.2019.112230 - DOI - PubMed
1. Hoffmann, M. , Kleine‐Weber, H. , Schroeder, S. , Krüger, N. , Herrler, T. , Erichsen, S. , … Nitsche, A. (2020). SARS‐CoV‐2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 181, 271–280.e8. 10.1016/j.cell.2020.02.052 - DOI - PMC - PubMed

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[1] Bugge, T. H. , Antalis, T. M. , & Wu, Q. (2009). Type II transmembrane serine proteases. Journal of Biological Chemistry, 284(35), 23177–23181. - PMC - PubMed

[2] Bugge, T. H. , Antalis, T. M. , & Wu, Q. (2009). Type II transmembrane serine proteases. Journal of Biological Chemistry, 284(35), 23177–23181. - PMC - PubMed

[3] Fan, H. H. , Wang, L. Q. , Liu, W. L. , An, X. P. , Liu, Z. D. , He, X. Q. , … Tong, Y. G. (2020). Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019‐novel coronavirus (2019‐nCoV) related coronavirus model. Chinese Medical Journal, 1. 10.1097/CM9.0000000000000797 - DOI - PMC - PubMed

[4] Fan, H. H. , Wang, L. Q. , Liu, W. L. , An, X. P. , Liu, Z. D. , He, X. Q. , … Tong, Y. G. (2020). Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019‐novel coronavirus (2019‐nCoV) related coronavirus model. Chinese Medical Journal, 1. 10.1097/CM9.0000000000000797 - DOI - PMC - PubMed

[5] Han, L. P. , Sun, B. , Li, C. J. , Xie, Y. , & Chen, L. M. (2018). Effect of celastrol on toll‐like receptor 4‐mediated inflammatory response in free fatty acid‐induced HepG2 cells. International Journal of Molecular Medicine, 42(4), 2053–2061. - PMC - PubMed

[6] Han, L. P. , Sun, B. , Li, C. J. , Xie, Y. , & Chen, L. M. (2018). Effect of celastrol on toll‐like receptor 4‐mediated inflammatory response in free fatty acid‐induced HepG2 cells. International Journal of Molecular Medicine, 42(4), 2053–2061. - PMC - PubMed

[7] Heinrich, M. , Appendino, G. , Efferth, T. , Fürst, R. , Izzo, A. A. , Kayser, O. , … Viljoen, A. (2020). Best practice in research–overcoming common challenges in phytopharmacological research. Journal of Ethnopharmacology, 246, 112230. 10.1016/j.jep.2019.112230 - DOI - PubMed

[8] Heinrich, M. , Appendino, G. , Efferth, T. , Fürst, R. , Izzo, A. A. , Kayser, O. , … Viljoen, A. (2020). Best practice in research–overcoming common challenges in phytopharmacological research. Journal of Ethnopharmacology, 246, 112230. 10.1016/j.jep.2019.112230 - DOI - PubMed

[9] Hoffmann, M. , Kleine‐Weber, H. , Schroeder, S. , Krüger, N. , Herrler, T. , Erichsen, S. , … Nitsche, A. (2020). SARS‐CoV‐2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 181, 271–280.e8. 10.1016/j.cell.2020.02.052 - DOI - PMC - PubMed

[10] Hoffmann, M. , Kleine‐Weber, H. , Schroeder, S. , Krüger, N. , Herrler, T. , Erichsen, S. , … Nitsche, A. (2020). SARS‐CoV‐2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell, 181, 271–280.e8. 10.1016/j.cell.2020.02.052 - DOI - PMC - PubMed

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Should we try the antiinflammatory natural product, celastrol, for COVID-19?

Affiliations

Should we try the antiinflammatory natural product, celastrol, for COVID-19?

Authors

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