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. 2020 Apr 27:ciaa478.
doi: 10.1093/cid/ciaa478. Online ahead of print.

Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19

Adarsh Bhimraj  1 , Rebecca L Morgan  2 , Amy Hirsch Shumaker  3 , Valery Lavergne  4 , Lindsey Baden  5 , Vincent Chi-Chung Cheng  6 , Kathryn M Edwards  7 , Rajesh Gandhi  8 , William J Muller  9 , John C O'Horo  10 , Shmuel Shoham  11 , M Hassan Murad  12 , Reem A Mustafa  13 , Shahnaz Sultan  14 , Yngve Falck-Ytter  3
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Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19

Adarsh Bhimraj et al. Clin Infect Dis. .

Abstract

Background: There are many pharmacologic therapies that are being used or considered for treatment of COVID-19. There is a need for frequently updated practice guidelines on their use, based on critical evaluation of rapidly emerging literature.

Objective: Develop evidence-based rapid guidelines intended to support patients, clinicians and other health-care professionals in their decisions about treatment and management of patients with COVID-19.

Methods: IDSA formed a multidisciplinary guideline panel of infectious disease clinicians, pharmacists, and methodologists with varied areas of expertise. Process followed a rapid recommendation checklist. The panel prioritized questions and outcomes. Then a systematic review of the peer-reviewed and grey literature was conducted. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence and make recommendations.

Results: The IDSA guideline panel agreed on 7 treatment recommendations and provided narrative summaries of other treatments undergoing evaluations.

Conclusions: The panel expressed the overarching goal that patients be recruited into ongoing trials, which would provide much needed evidence on the efficacy and safety of various therapies for COVID-19, given that we could not make a determination whether the benefits outweigh harms for most treatments.

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