A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

doi:10.1016/j.jaci.2020.04.013

Case Reports

. 2020 Jul;146(1):211-213.e4.

doi: 10.1016/j.jaci.2020.04.013. Epub 2020 Apr 22.

A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

Affiliations

¹ Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address: isabella.quinti@uniroma1.it.
² Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; ASST-Spedali Civili di Brescia, Brescia, Italy.
³ Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
⁴ Department of Medicine, University of Padua, Padua, Italy; Internal Medicine I, Ca' Foncello Hospital, Treviso, Italy.
⁵ Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
⁶ Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
⁷ Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
⁸ Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
⁹ 2nd Division of Anesthesia and ICU, ASST-Spedali Civili di Brescia, Brescia, Italy.
¹⁰ Paediatric Unit, ASST-Spedali Civili di Brescia, Brescia, Italy.
¹¹ Diagnostic Immunology Unit, Department of Laboratories, B Cell Pathophysiology Unit, Immunology Research Area, Bambino Gesù Children's Hospital, Rome, Italy.

PMID: 32333914
PMCID: PMC7175894
DOI: 10.1016/j.jaci.2020.04.013

Case Reports

A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

Isabella Quinti et al. J Allergy Clin Immunol. 2020 Jul.

. 2020 Jul;146(1):211-213.e4.

doi: 10.1016/j.jaci.2020.04.013. Epub 2020 Apr 22.

Authors

Affiliations

¹ Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy. Electronic address: isabella.quinti@uniroma1.it.
² Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy; ASST-Spedali Civili di Brescia, Brescia, Italy.
³ Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
⁴ Department of Medicine, University of Padua, Padua, Italy; Internal Medicine I, Ca' Foncello Hospital, Treviso, Italy.
⁵ Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
⁶ Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
⁷ Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
⁸ Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
⁹ 2nd Division of Anesthesia and ICU, ASST-Spedali Civili di Brescia, Brescia, Italy.
¹⁰ Paediatric Unit, ASST-Spedali Civili di Brescia, Brescia, Italy.
¹¹ Diagnostic Immunology Unit, Department of Laboratories, B Cell Pathophysiology Unit, Immunology Research Area, Bambino Gesù Children's Hospital, Rome, Italy.

PMID: 32333914
PMCID: PMC7175894
DOI: 10.1016/j.jaci.2020.04.013

No abstract available

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Figures

**Fig. 1**
Lung HRCT in a patient with CVID at admission, showing extensive ground glass opacities associated with areas of alveolar consolidation in the lower lobes, where the alveolar component predominates over the interstitial component (A [*left, mid-upper; right: lower*), and after treatment, showing reduction in extent of ground glass opacities and areas of alveolar consolidation (B [*left, mid-upper; right, lower*]). Lung HRCT in a patient with agammaglobulinemia. Axial sections showing bronchiectasis and sequelae of right lung pneumonectomy (in March 2020 [C] and January 2019 [D]).

See this image and copyright information in PMC

Comment in

COVID-19 infection in 10 common variable immunodeficiency patients in New York City.
Cohen B, Rubinstein R, Gans MD, Deng L, Rubinstein A, Eisenberg R. Cohen B, et al. J Allergy Clin Immunol Pract. 2021 Jan;9(1):504-507.e1. doi: 10.1016/j.jaip.2020.11.006. Epub 2020 Nov 18. J Allergy Clin Immunol Pract. 2021. PMID: 33217615 Free PMC article. No abstract available.

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References

1. Fauci A.S., Lane H.C., Redfield R.R. Covid-19 - navigating the uncharted. N Engl J Med. 2020;382:1268–1269. - PMC - PubMed
1. Seidel M.G., Kindle G., Gathmann B., Quinti I., Buckland M., van Montfrans J. The European Society for Immunodeficiencies (ESID) Registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract. 2019;7:1763–1770. - PubMed
1. Burton D.R. Antibodies, viruses and vaccines. Nat Rev Immunol. 2002;2:706–713. - PubMed
1. Jones T.P.W., Buckland M., Breuer J., Lowe D.M. Viral infection in primary antibody deficiency syndromes. Rev Med Virol. 2019;29:e2049. - PubMed
1. Lougaris V., Soresina A., Baronio M., Montin D., Martino S., Signa S. Long term follow-up of 168 patients with X-linked agammaglobulinemia reveals increased morbidity and mortality. J Allergy Clin Immunol. 2020;6749:30330–30334. - PubMed

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[1] Fauci A.S., Lane H.C., Redfield R.R. Covid-19 - navigating the uncharted. N Engl J Med. 2020;382:1268–1269. - PMC - PubMed

[2] Fauci A.S., Lane H.C., Redfield R.R. Covid-19 - navigating the uncharted. N Engl J Med. 2020;382:1268–1269. - PMC - PubMed

[3] Seidel M.G., Kindle G., Gathmann B., Quinti I., Buckland M., van Montfrans J. The European Society for Immunodeficiencies (ESID) Registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract. 2019;7:1763–1770. - PubMed

[4] Seidel M.G., Kindle G., Gathmann B., Quinti I., Buckland M., van Montfrans J. The European Society for Immunodeficiencies (ESID) Registry working definitions for the clinical diagnosis of inborn errors of immunity. J Allergy Clin Immunol Pract. 2019;7:1763–1770. - PubMed

[5] Burton D.R. Antibodies, viruses and vaccines. Nat Rev Immunol. 2002;2:706–713. - PubMed

[6] Burton D.R. Antibodies, viruses and vaccines. Nat Rev Immunol. 2002;2:706–713. - PubMed

[7] Jones T.P.W., Buckland M., Breuer J., Lowe D.M. Viral infection in primary antibody deficiency syndromes. Rev Med Virol. 2019;29:e2049. - PubMed

[8] Jones T.P.W., Buckland M., Breuer J., Lowe D.M. Viral infection in primary antibody deficiency syndromes. Rev Med Virol. 2019;29:e2049. - PubMed

[9] Lougaris V., Soresina A., Baronio M., Montin D., Martino S., Signa S. Long term follow-up of 168 patients with X-linked agammaglobulinemia reveals increased morbidity and mortality. J Allergy Clin Immunol. 2020;6749:30330–30334. - PubMed

[10] Lougaris V., Soresina A., Baronio M., Montin D., Martino S., Signa S. Long term follow-up of 168 patients with X-linked agammaglobulinemia reveals increased morbidity and mortality. J Allergy Clin Immunol. 2020;6749:30330–30334. - PubMed

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A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

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A possible role for B cells in COVID-19? Lesson from patients with agammaglobulinemia

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