The proximal origin of SARS-CoV-2

doi:10.1038/s41591-020-0820-9

. 2020 Apr;26(4):450-452.

doi: 10.1038/s41591-020-0820-9.

The proximal origin of SARS-CoV-2

Kristian G Andersen^{1

2}, Andrew Rambaut³, W Ian Lipkin⁴, Edward C Holmes⁵, Robert F Garry^{6

7}

Affiliations

¹ Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. andersen@scripps.edu.
² Scripps Research Translational Institute, La Jolla, CA, USA. andersen@scripps.edu.
³ Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
⁴ Center for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, NY, USA.
⁵ Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, Australia.
⁶ Tulane University, School of Medicine, Department of Microbiology and Immunology, New Orleans, LA, USA.
⁷ Zalgen Labs, Germantown, MD, USA.

PMID: 32284615
PMCID: PMC7095063
DOI: 10.1038/s41591-020-0820-9

The proximal origin of SARS-CoV-2

Kristian G Andersen et al. Nat Med. 2020 Apr.

. 2020 Apr;26(4):450-452.

doi: 10.1038/s41591-020-0820-9.

Authors

Kristian G Andersen^{1

2}, Andrew Rambaut³, W Ian Lipkin⁴, Edward C Holmes⁵, Robert F Garry^{6

7}

Affiliations

¹ Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. andersen@scripps.edu.
² Scripps Research Translational Institute, La Jolla, CA, USA. andersen@scripps.edu.
³ Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK.
⁴ Center for Infection and Immunity, Mailman School of Public Health of Columbia University, New York, NY, USA.
⁵ Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, Australia.
⁶ Tulane University, School of Medicine, Department of Microbiology and Immunology, New Orleans, LA, USA.
⁷ Zalgen Labs, Germantown, MD, USA.

PMID: 32284615
PMCID: PMC7095063
DOI: 10.1038/s41591-020-0820-9

No abstract available

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Conflict of interest statement

R.F.G. is co-founder of Zalgen Labs, a biotechnology company that develops countermeasures to emerging viruses.

Figures

**Fig. 1. Features of the spike protein in human SARS-CoV-2 and related coronaviruses.**
a, Mutations in contact residues of the SARS-CoV-2 spike protein. The spike protein of SARS-CoV-2 (red bar at top) was aligned against the most closely related SARS-CoV-like coronaviruses and SARS-CoV itself. Key residues in the spike protein that make contact to the ACE2 receptor are marked with blue boxes in both SARS-CoV-2 and related viruses, including SARS-CoV (Urbani strain). b, Acquisition of polybasic cleavage site and O-linked glycans. Both the polybasic cleavage site and the three adjacent predicted O-linked glycans are unique to SARS-CoV-2 and were not previously seen in lineage B betacoronaviruses. Sequences shown are from NCBI GenBank, accession codes MN908947, MN996532, AY278741, KY417146 and MK211376. The pangolin coronavirus sequences are a consensus generated from SRR10168377 and SRR10168378 (NCBI BioProject PRJNA573298)^,.

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Comment in

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References

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[1] Zhou P, et al. Nature. 2020 doi: 10.1038/s41586-020-2012-7. - DOI - PubMed

[2] Zhou P, et al. Nature. 2020 doi: 10.1038/s41586-020-2012-7. - DOI - PubMed

[3] Wu F, et al. Nature. 2020 doi: 10.1038/s41586-020-2008-3. - DOI - PubMed

[4] Wu F, et al. Nature. 2020 doi: 10.1038/s41586-020-2008-3. - DOI - PubMed

[5] Gorbalenya AE, et al. bioRxiv. 2020 doi: 10.1101/2020.02.07.937862. - DOI

[6] Gorbalenya AE, et al. bioRxiv. 2020 doi: 10.1101/2020.02.07.937862. - DOI

[7] Jiang S, et al. Lancet. 2020 doi: 10.1016/S0140-6736(20)30419-0. - DOI - PMC - PubMed

[8] Jiang S, et al. Lancet. 2020 doi: 10.1016/S0140-6736(20)30419-0. - DOI - PMC - PubMed

[9] Dong E, Du H, Gardner L. Lancet Infect. Dis. 2020 doi: 10.1016/S1473-3099(20)30120-1. - DOI - PMC - PubMed

[10] Dong E, Du H, Gardner L. Lancet Infect. Dis. 2020 doi: 10.1016/S1473-3099(20)30120-1. - DOI - PMC - PubMed

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The proximal origin of SARS-CoV-2

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The proximal origin of SARS-CoV-2

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