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. 2020 May 1;25(3):e375-e382.
doi: 10.4317/medoral.23410.

Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma

P-G Barros-Silva  1 , M-M Fontes-Borges, C Costa-Dias, J-V Mota-Lemos, M-D Socorro-Saldanha-Cunha, E Fernandes-Souza, T Sousa-Dantas, F Bitu-Sousa
Affiliations

Clinical-pathological and sociodemographic factors associated with the distant metastasis and overall survival of oral cavity and oropharynx squamous cell carcinoma

P-G Barros-Silva et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: The objective of this study was to evaluate the influence of clinical-pathological and sociodemographic factors on the prevalence of distant metastasis (DM) and overall survival in patients with oral cavity and oropharynx squamous cell carcinoma (OOSCC).

Material and methods: Cross-sectional study based on the records of 404 OOSCC patients evaluated for DM, covering the period 2000-2014. We analysed the influence of age, sex, level of schooling, primary tumor subsite, treatment, marital status, family history of cancer, history of smoking and alcohol consumption, type of health care coverage (private vs. public) and overall survival. Findings were submitted to Fisher's exact test, Pearson's chi-squared test, Mantel-Cox log-rank testing and multinomial and Cox regression analysis (SPSS v. 20.0; p<0.05).

Results: The prevalence of DM was 5.4% (22/404). The respiratory tract was the most affected DM site (n=9; 40.9%). Male sex (p=0.049), oropharyngeal primary tumor (p=0.008), stage T3-4 (p=0.022), lymph node metastasis (N+) (p<0.001) and palliative treatment (p=0.005) were directly associated with DM. Patients with oral primary tumours (p=0.343) and primary oropharyngeal tumours (p=0.242) did not differ significantly with regard to the prevalence of DM. N+ was an independent risk factor for DM (p=0.017). Five variables independently reduced overall survival: male sex (p=0.035), age >65 years (p=0.046), indigenous/brown racial type (p=0.045), palliative treatment (p=0.035) and DM (p=0.048).

Conclusions: Lymph node metastasis independently increased the prevalence of DM and, along with male sex, older age, brown racial type and palliative treatment, was independently associated with poor prognosis in patients with OOSCC.

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Conflict of interest statement

Conflicts of interest None declared.

Figures

Figure 1
Figure 1
15-year follow-up and global survival of patients with squamous cell carcinoma of the oral cavity and oropharynx (OOSCC) treated at Hospital Haroldo Juaçaba (Ceará Cancer Institute) between 1 January 2000 and 31 December 2014 (Kaplan-Meier method).
See this image and copyright information in PMC

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