Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway
- PMID: 32204114
- DOI: 10.1016/j.msec.2020.110686
Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway
Abstract
Difficult healing of skin wounds is one of the serious complications of diabetes mellitus. Green tea polyphenols (TP) have been found to have good therapeutic effects on wounds healing. However, TP that is soluble in water and easily been oxidized requires a gel material that provides moisture retention, oxidation prevention, and sustained release of TP to achieve better wound healing effect. Therefore, in this work, novel tea polyphenol nanospheres (TPN) were synthesized and encapsulated in a PVA /alginate hydrogel (TPN@H). The prepared TPN@H was characterized and applicated in model diabetic rats for promoting wound healing and regulating immune response. Fourier-transform infrared spectroscopy (FT-IR), UV spectroscopy, scanning electron microscopy (SEM), atomic force microscope (AFM), confocal laser scanning microscopy (CLSM), dynamic light scattering (DLS) and differential scanning calorimetry (DSC) were used for characterization. Animal experiments and molecular mechanism research proved that TPN@H could promote wound healing of diabetic rats by regulating PI3K/AKT signaling pathway.
Keywords: Diabetic wound healing; Green tea polyphenols; Hydrogels; Nanospheres.
Copyright © 2020 Elsevier B.V. All rights reserved.
Conflict of interest statement
Declaration of competing interest None.
Similar articles
-
Tea polyphenol modified, photothermal responsive and ROS generative black phosphorus quantum dots as nanoplatforms for promoting MRSA infected wounds healing in diabetic rats.J Nanobiotechnology. 2021 Nov 10;19(1):362. doi: 10.1186/s12951-021-01106-w. J Nanobiotechnology. 2021. PMID: 34758829 Free PMC article.
-
Silver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits.Int J Pharm. 2019 Mar 25;559:23-36. doi: 10.1016/j.ijpharm.2019.01.019. Epub 2019 Jan 19. Int J Pharm. 2019. PMID: 30668991
-
Triethyl orthoformate mediated a novel crosslinking method for the preparation of hydrogels for tissue engineering applications: characterization and in vitro cytocompatibility analysis.Mater Sci Eng C Mater Biol Appl. 2015 Nov 1;56:154-64. doi: 10.1016/j.msec.2015.06.021. Epub 2015 Jun 14. Mater Sci Eng C Mater Biol Appl. 2015. PMID: 26249576
-
Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing.J Mater Chem B. 2024 Oct 17;12(40):10163-10197. doi: 10.1039/d4tb01049c. J Mater Chem B. 2024. PMID: 39283024 Review.
-
Alginate hydrogel dressings for advanced wound management.Int J Biol Macromol. 2020 Nov 1;162:1414-1428. doi: 10.1016/j.ijbiomac.2020.07.311. Epub 2020 Aug 7. Int J Biol Macromol. 2020. PMID: 32777428 Review.
Cited by
-
Predatory bacterial hydrogels for topical treatment of infected wounds.Acta Pharm Sin B. 2023 Jan;13(1):315-326. doi: 10.1016/j.apsb.2022.05.005. Epub 2022 May 13. Acta Pharm Sin B. 2023. PMID: 36815028 Free PMC article.
-
Fluro-Protein C-Phycocyanin Docked Silver Nanocomposite Accelerates Cell Migration through NFĸB Signaling Pathway.Int J Mol Sci. 2023 Feb 6;24(4):3184. doi: 10.3390/ijms24043184. Int J Mol Sci. 2023. PMID: 36834597 Free PMC article.
-
3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery.Pharmaceutics. 2021 Nov 17;13(11):1946. doi: 10.3390/pharmaceutics13111946. Pharmaceutics. 2021. PMID: 34834360 Free PMC article. Review.
-
Modulation of Rat Kidney Stone Crystallization and the Relative Oxidative Stress Pathway by Green Tea Polyphenol.ACS Omega. 2021 Jan 7;6(2):1725-1731. doi: 10.1021/acsomega.0c05903. eCollection 2021 Jan 19. ACS Omega. 2021. PMID: 33490831 Free PMC article.
-
Effects of poly(vinyl alcohol) blending with Ag/alginate solutions to form nanocomposite fibres for potential use as antibacterial wound dressings.R Soc Open Sci. 2022 Mar 30;9(3):211517. doi: 10.1098/rsos.211517. eCollection 2022 Mar. R Soc Open Sci. 2022. PMID: 35360353 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
