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Case Reports
. 2020 Jul;75(7):1699-1709.
doi: 10.1111/all.14289. Epub 2020 Apr 6.

Eleven faces of coronavirus disease 2019

Xiang Dong  1 , Yi-Yuan Cao  2 , Xiao-Xia Lu  3 , Jin-Jin Zhang  1 , Hui Du  3 , You-Qin Yan  4 , Cezmi A Akdis  5 , Ya-Dong Gao  1
Affiliations
Case Reports

Eleven faces of coronavirus disease 2019

Xiang Dong et al. Allergy. 2020 Jul.

Abstract

Background and aims: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has recently spread worldwide and been declared a pandemic. We aim to describe here the various clinical presentations of this disease by examining eleven cases.

Methods: Electronic medical records of 11 patients with COVID-19 were collected, and demographics, clinical manifestations, outcomes, key laboratory results, and radiological images are discussed.

Results: The clinical course of the eleven cases demonstrated the complexity of the COVID-19 profile with different clinical presentations. Clinical manifestations range from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Laboratory detection of the viral nucleic acid can yield false-negative results, and serological testing of virus-specific IgG and IgM antibodies should be used as an alternative for diagnosis. Patients with common allergic diseases did not develop distinct symptoms and severe courses. Cases with a pre-existing condition of chronic obstructive pulmonary disease or complicated with a secondary bacterial pneumonia were more severe.

Conclusion: All different clinical characteristics of COVID-19 should be taken into consideration to identify patients that need to be in strict quarantine for the efficient containment of the pandemic.

Keywords: SARS-CoV-2; allergic diseases; case reports; clinical characteristics; coronavirus disease 2019.

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Figures

Figure 1
Figure 1
Chest CT images of case 3. (A) Patchy ground‐glass opacities in left upper lobe on January 30; (B) progressed bilateral multiple ground‐glass opacities on February 6
Figure 2
Figure 2
Chest CT images of case 5. (A‐C) Multiple focal ground‐glass opacities in both lower lobes on January 23; (D‐E) bilateral multiple patchy ground‐glass opacities mixed consolidation and fibrous stripes on January 31
Figure 3
Figure 3
Chest CT and X‐ray images of case 6. (A) Bilateral scattered patchy opacities on January 19; (B) bilateral extended ground‐glass opacities with scattered consolidation on January 23; (C‐E) bilateral progressive consolidation and pleural effusion on February 2, 8, and 15, respectively
Figure 4
Figure 4
Chest CT images of two children with COVID‐19. (A) On January 25, case 7 showed isolated patchy consolidation in the upper left lobe; (B) On January 28, case 8 showed bilateral diffuse patchy opacities distributed around the bronchovascular area
Figure 5
Figure 5
Chest CT images of case 10. (A, B) Images of two layers showing emphysema and bullae in both lungs and bilateral ground‐glass opacities and consolidation on January 22
Figure 6
Figure 6
Chest CT images of case 11. (A) Bilateral multiple ground‐glass opacities and consolidation on February 2; (B) partly absorbed bilateral ground‐glass opacities and consolidation on February 9
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