Recent Advances in the Development of Biomarkers and Chemoradiotherapeutic Approaches for Nasopharyngeal Carcinoma
- PMID: 32191137
- DOI: 10.1200/EDBK_280747
Recent Advances in the Development of Biomarkers and Chemoradiotherapeutic Approaches for Nasopharyngeal Carcinoma
Abstract
Epstein-Barr virus (EBV) associated nasopharyngeal carcinoma (NPC) is endemic in Southern China, and the prognosis of this cancer has improved in part due to advances in radiotherapy (RT) techniques, broadened therapeutic options, and more precise prognostic stratification of patients. RT is the primary curative treatment of NPC, and the incorporation of chemotherapy (induction, concurrent, adjuvant) to RT has contributed to improved survival in patients with locoregionally advanced NPC. Concurrent chemoradiotherapy (CCRT) in combination with adjuvant or induction chemotherapy is now the standard treatment of locoregionally advanced NPC, but the ideal CCRT therapeutic strategy for NPC remains controversial. Plasma EBV DNA is the archetypal tumor-derived DNA in NPC, and three generations of studies have gradually expanded its clinical applications. Recently, the advent of whole exome/genome sequencing of NPC and the promising clinical activity of immune checkpoint inhibitors have also spurred interest in the development of newer biomarkers. This review will focus on two clinical advances in NPC research that have made substantial impact on the contemporary management of NPC: (1) The integration of plasma EBV DNA in an expanding spectrum of clinical indications, and the development of promising immune-related biomarkers; (2) the current development of CCRT with special emphasis on the use of induction and adjuvant chemotherapy, as well as the potential applications of metronomic chemotherapy and immune checkpoint inhibitors in the treatment of locoregionally advanced NPC.
Similar articles
-
Early Stage and Locally Advanced Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Going?Curr Treat Options Oncol. 2023 Jul;24(7):845-866. doi: 10.1007/s11864-023-01083-2. Epub 2023 May 5. Curr Treat Options Oncol. 2023. PMID: 37145382 Free PMC article. Review.
-
Concurrent chemoradiotherapy with/without induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma: Long-term results of phase 3 randomized controlled trial.Int J Cancer. 2019 Jul 1;145(1):295-305. doi: 10.1002/ijc.32099. Epub 2019 Jan 24. Int J Cancer. 2019. PMID: 30613964 Clinical Trial.
-
Induction chemotherapy plus IMRT alone versus induction chemotherapy plus IMRT-based concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: a retrospective cohort study.J Cancer Res Clin Oncol. 2019 Jul;145(7):1857-1864. doi: 10.1007/s00432-019-02925-z. Epub 2019 May 6. J Cancer Res Clin Oncol. 2019. PMID: 31062162
-
Five-year disease-free survival of Epstein-Barr virus-associated locoregionally advanced undifferentiated nasopharyngeal carcinoma patients treated with chemo-radiotherapy: a case report.Ann Palliat Med. 2022 Mar;11(3):1147-1152. doi: 10.21037/apm-22-168. Ann Palliat Med. 2022. PMID: 35365045
-
Chemotherapy in locoregionally advanced nasopharyngeal carcinoma-a review.J BUON. 2008 Oct-Dec;13(4):495-503. J BUON. 2008. PMID: 19145670 Review.
Cited by
-
Early Stage and Locally Advanced Nasopharyngeal Carcinoma Treatment from Present to Future: Where Are We and Where Are We Going?Curr Treat Options Oncol. 2023 Jul;24(7):845-866. doi: 10.1007/s11864-023-01083-2. Epub 2023 May 5. Curr Treat Options Oncol. 2023. PMID: 37145382 Free PMC article. Review.
-
Development and validation of a risk prediction model for overall survival in patients with nasopharyngeal carcinoma: a prospective cohort study in China.Cancer Cell Int. 2022 Nov 19;22(1):360. doi: 10.1186/s12935-022-02776-8. Cancer Cell Int. 2022. PMID: 36403013 Free PMC article.
-
Performance of Plasma HSP90α, Serum EBV VCA IgA Antibody and Plasma EBV DNA for the Diagnosis and Prognosis Prediction of Nasopharyngeal Carcinoma.Cancer Manag Res. 2021 Jul 20;13:5793-5802. doi: 10.2147/CMAR.S320541. eCollection 2021. Cancer Manag Res. 2021. PMID: 34321926 Free PMC article.
-
Nasopharyngeal carcinoma: an evolving paradigm.Nat Rev Clin Oncol. 2021 Nov;18(11):679-695. doi: 10.1038/s41571-021-00524-x. Epub 2021 Jun 30. Nat Rev Clin Oncol. 2021. PMID: 34194007 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources