Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb 27:10:267.
doi: 10.3389/fonc.2020.00267. eCollection 2020.

RNA-seq Analysis of Wild-Type vs. FOXC2-Deficient Melanoma Cells Reveals a Role for the FOXC2 Transcription Factor in the Regulation of Multiple Oncogenic Pathways

Kristian M Hargadon  1 , Corey J Williams  1
Affiliations

RNA-seq Analysis of Wild-Type vs. FOXC2-Deficient Melanoma Cells Reveals a Role for the FOXC2 Transcription Factor in the Regulation of Multiple Oncogenic Pathways

Kristian M Hargadon et al. Front Oncol. .
No abstract available

Keywords: FOXC2; RNA-seq; differential expression; gene regulation; melanoma; oncogene.

PubMed Disclaimer

Figures

Figure 1
Figure 1
RNA-seq correlation and differential gene expression analyses of B16-F1 and B16-F1ΔFOXC2 murine melanomas. RNA-seq analysis was performed on RNA isolated from five replicate samples for each biological group. The Pearson R2 correlation heat map of gene expression levels between all samples is shown in (A). The hierarchical clustering heat map of differentially expressed genes between B16-F1 and B16-F1ΔFOXC2 is shown in (B). KEGG Pathway and Gene Ontology analyses were performed to identify pathways and biological processes significantly enriched with differentially upregulated and downregulated genes in B16-F1. Enrichment score dot plots showing gene counts and statistical significance as determined by a Fisher's exact test are presented for the top 10 KEGG pathways enriched in differentially expressed (DE) genes in (C,D) and for the top 10 Biologic Process-related GO Terms enriched in DE genes in (E,F).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, et al. . Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci USA. (2007) 104:10069–74. 10.1073/pnas.0703900104 - DOI - PMC - PubMed
    1. Børretzen A, Gravdal K, Haukaas SA, Beisland C, Akslen LA, Halvorsen OJ. FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer. J Pathol Clin Res. (2019) 5:272–86. 10.1002/cjp2.142 - DOI - PMC - PubMed
    1. Shimoda Y, Ubukata Y, Handa T, Yokobori T, Watanabe T, Gantumur D, et al. . High expression of forkhead box protein C2 is associated with aggressive phenotypes and poor prognosis in clinical hepatocellular carcinoma. BMC Cancer. (2018) 18:597. 10.1186/s12885-018-4503-6 - DOI - PMC - PubMed
    1. Jiang W, Fan H, Qian C, Ding J, Wang Q, Pang X. Prognostic value of high FoxC2 expression in resectable non-small cell lung cancer, alone or in combination with E-cadherin expression. BMC Cancer. (2016) 16:16 10.1186/s12885-016-2056-0 - DOI - PMC - PubMed
    1. Cui YM, Jiang D, Zhang SH, Wu P, Ye YP, Chen CM, et al. . FOXC2 promotes colorectal cancer proliferation through inhibition of FOXO3a and activation of MAPK and AKT signaling pathways. Cancer Lett. (2014) 353:87–94. 10.1016/j.canlet.2014.07.008 - DOI - PubMed