doi: 10.1016/j.ceca.2020.102186.
Epub 2020 Feb 24.
A trio has turned into a quartet: DJ-1 interacts with the IP3R-Grp75-VDAC complex to control ER-mitochondria interaction
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- PMID: 32120195
- DOI: 10.1016/j.ceca.2020.102186
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A trio has turned into a quartet: DJ-1 interacts with the IP3R-Grp75-VDAC complex to control ER-mitochondria interaction
Cell Calcium.
2020 May.
Abstract
The outer mitochondrial membrane protein VDAC interacts with the ER protein IP3R via chaperone Grp75 to form a molecular complex that couples mitochondria to the ER and contributes to functional mitochondria-ER contacts (MERCs), essential for efficient calcium (Ca2+) transfer. A new study by Liu et al. identifies the PD protein DJ-1 as a component of the IP3R-Grp75-VDAC complex. DJ-1 ablation impairs mitochondria-ER association and Ca2+ crosstalk, and impacts the stability of the trio.
Keywords: Calcium (Ca(2+)); DJ-1; MERCs; Parkinson’s disease.
Copyright © 2020 Elsevier Ltd. All rights reserved.
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