Disclosure FC has received fees for consultancy/advisory roles from Amgen, Astellas/Medivation, AstraZeneca, Celgene, Daiichi-Sankyo, Eisai, GE Oncology, Genentech, GlaxoSmithKline, Macrogenics, Medspace, Merck-Sharp, Merus BV, Mylan, Mundipharma, Novartis, Pfizer, Pierre-Fabre, prIME Oncology, Roche, Sanofi, Seatlle Genetics and Teva. RD has received fees for consultancy/advisory roles from AstraZeneca, Eisai, Lilly, Merck, Novartis, Pfizer, Roche, and for travel and subsistence from Roche, Merck, Pfizer, Eisai. SG has received research funding from Roche, Sanofi, Johnson & Johnson, Oncostem, Amgen, Celltrion, Novartis, Eisai, Intas and Biocon. S-AI has received fees for consultancy/advisory roles from Amgen, AstraZeneca, Hanmi Corp, Medpacto, Pfizer, Eisai, Novartis, Roche and Lilly, and research funding from AstraZeneca, Pfizer and Roche. HI has received fees for consultancy/advisory roles from Chugai, AstraZeneca, Lilly, Daiich-Sankyo, Pfizer, MSD, Eisai, Kyowa Hakko Kirin, Taiho and Novartis, and research funding from Chugai, AstraZeneca, Lilly, Daiich-Sankyo, Pfizer, MSD, Kyowa Hakko Kirin, Bayer, Novartis and GSK. JHK has received research funding from Ono Pharma Korea Co., Ltd. SCL has received fees for consultancy/advisory roles from Roche, Pfizer, Novartis, Eli Lilly, AstraZeneca and research funding from Taiho, ACT Genomics, Eisai and Pfizer. Y-SL has received fees for consultancy/advisory roles from Pfizer, MSD, Novartis, Boehringer-Ingelheim and Roche, and research funding from MSD, Novartis and Roche. SM has received fees for consultancy/advisory roles from MSD and research funding from ASLAN Pharmaceuticals, MSD, Novartis, Astellas and AstraZeneca. MYM has received research funding from MSD, Mundi Pharma, Astellas, Novartis, AstraZeneca, Sanofi, Roche and Pfizer. YHP has received fees for consultancy/advisory roles from AstraZeneca, Pfizer, Eisai, Novartis, Merck, Roche and Lilly, and research funding from AstraZeneca, Eisai, Merck, Pfizer, Novartis and Roche. GP has received fees for consultancy/advisory roles from Roche, Amgen, MSD, Boehringer and Bristol-Myers Squibb, and research funding from Roche, Amgen, Astellas, Pfizer and Novartis. SS has received fees for consultancy/advisory roles from Novartis, Chugai and Kyowa Kirin, research funding from Chugai, Takeda, Eisai, Taiho and Novartis, and fees for non-CME services received directly from commercial interests or their agents (e.g. speakers bureau) from Pfizer, Novartis, AstraZeneca, Eli Lilly, Eisai, Kyowa Kirin and Chugai, and is an executive board member of the Japan Breast Cancer Society (JBCS) and the Japan Breast Cancer Research Group (JBCRG). ES has received honoraria from Amgen, AstraZeneca, Clinigen, EGIS Pharmaceuticals, Eli Lilly, Genomic Health, Novartis, Pfizer, Pierre Fabre, Roche, Sandoz and TLC Biopharmaceuticals, travel support from Amgen, AstraZeneca, EGIS Pharmaceuticals, Novartis, Pfizer and Roche, and clinical research funding from Amgen, AstraZeneca, Boehringer, Eli Lilly, Merck, Novartis, Pfizer, Roche and Samsung. BKS has received fees for consultancy/advisory roles from Eli Lilly, Dr Reddy's Lab, Cipla and AstraZeneca. TT has received fees for consultancy/advisory roles from AstraZeneca and research funding from Eisai, Chugai, and Novartis Pharma. TY has received research funding from Novartis Pharma K.K., MSD K.K., Sumitomo Dainippon Pharma Co., Ltd., Chugai Pharmaceutical Co., Ltd., Sanofi K.K., Daiichi Sankyo Co., Ltd., Parexel International Inc., ONO Pharmaceutical Co., Ltd., GlaxoSmithKline K.K., Boehringer Ingleheim Japan, Inc. J-YD, T-YK, KJS, L-MT and YY have declared no conflicts of interest.