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Review
. 2020 Apr;42(4):e1900157.
doi: 10.1002/bies.201900157. Epub 2020 Feb 20.

Debating Eukaryogenesis-Part 1: Does Eukaryogenesis Presuppose Symbiosis Before Uptake?

Dave Speijer  1
Affiliations
Review

Debating Eukaryogenesis-Part 1: Does Eukaryogenesis Presuppose Symbiosis Before Uptake?

Dave Speijer. Bioessays. 2020 Apr.

Abstract

Eukaryotic origins are heavily debated. The author as well as others have proposed that they are inextricably linked with the arrival of a pre-mitochondrion of alphaproteobacterial-like ancestry, in a so-called symbiogenic scenario. The ensuing mutual adaptation of archaeal host and endosymbiont seems to have been a defining influence during the processes leading to the last eukaryotic common ancestor. An unresolved question in this scenario deals with the means by which the bacterium ends up inside. Older hypotheses revolve around the application of known antagonistic interactions, the bacterium being prey or parasite. Here, in reviewing the field, the author argues that such models share flaws, hence making them less likely, and that a "pre-symbiotic stage" would have eased ongoing metabolic integration. Based on this the author will speculate about the nature of the (endo) symbiosis that started eukaryotic evolution-in the context of bacterial entry being a relatively "early" event-and stress the differences between this uptake and subsequent ones. He will also briefly discuss how the mutual adaptation following the merger progressed and how many eukaryotic hallmarks can be understood in light of coadaptation. Also see the video abstract here https://youtu.be/ekqtNleVJpU.

Keywords: Asgard archaea; eukaryogenesis; mitochondria; origin of sex; reactive oxygen species; symbiogenesis.

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References

    1. D. Quammen, The Tangled Tree, Simon & Schuster, New York 2018.
    1. V. L. Koumandou, B. Wickstead, M. L. Ginger, M. van der Giezen, J. B. Dacks, M. C. Field, Crit. Rev. Biochem. Mol. Biol. 2013, 48, 373.
    1. N. Lane, J. Theor. Biol. 2017, 434, 58.
    1. V. Zimorski, C. Ku, W. F. Martin, S. B. Gould, Curr. Opin. Microbiol. 2014, 22, 38.
    1. A. J. Roger, S. A. Munoz-Gomez, R. Kamikawa, Curr. Biol. 2017, 27, R1177.

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