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Meta-Analysis
. 2020 Jan 23:11:2.
doi: 10.3389/fendo.2020.00002. eCollection 2020.

Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis

Jiaxuan Qin  1   2   3 , Yufeng Yang  1   2   3 , Xuan Zhuang  1   2   3 , Jinchun Xing  1   2   3
Affiliations
Meta-Analysis

Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis

Jiaxuan Qin et al. Front Endocrinol (Lausanne). .

Abstract

Background: Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis. Methods: Studies associated with BAK1 rs210138 and TGCT was systematically searched in databases. The effect size was pooled according to ORs and 95% CIs. Results: Our systematic review and meta-analysis comprised 14 articles. Significantly increased risk of TGCT was found in eligible GWAS and follow-up studies, in overall group and its Caucasian subgroup. Conclusions: Compared with adenine (A), BAK1 rs210138 guanine (G) is associated with increased risk of TGCT. Well-planned studies with larger sample size and more subgroups are needed to verify the risk identified in our systematic review and meta-analysis.

Keywords: BAK1; meta-analysis; rs210138; single nucleotide polymorphisms; testicular germ cell tumors.

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Figures

Figure 1
Figure 1
Flow chart of study selection.
Figure 2
Figure 2
Forest plot with a fixed effects model for the association between BAK1 rs210138 and TGCT in allelic comparison (G vs. A) overall. For each study, the estimate of OR and its 95% CI is plotted with a box and a horizontal line. Rhombus: pooled OR and its 95% CI.
Figure 3
Figure 3
Forest plot with an I–V random effects model for the association between BAK1 rs210138 and TGCT in allelic comparison (G vs. A) in total. For each study, the estimate of OR and its 95% CI is plotted with a box and a horizontal line. Rhombus: pooled OR and its 95% CI.
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