Membrane and organelle dynamics during cell division

doi:10.1038/s41580-019-0208-1

Review

. 2020 Mar;21(3):151-166.

doi: 10.1038/s41580-019-0208-1. Epub 2020 Feb 7.

Membrane and organelle dynamics during cell division

Jeremy G Carlton^{1

2}, Hannah Jones^{3

4}, Ulrike S Eggert⁵

Affiliations

¹ School of Cancer and Pharmaceutical Sciences, King's College London, London, UK. jeremy.carlton@kcl.ac.uk.
² The Francis Crick Institute, London, UK. jeremy.carlton@kcl.ac.uk.
³ School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
⁴ The Francis Crick Institute, London, UK.
⁵ Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and Department of Chemistry, King's College London, London, UK. ulrike.eggert@kcl.ac.uk.

PMID: 32034394
DOI: 10.1038/s41580-019-0208-1

Review

Membrane and organelle dynamics during cell division

Jeremy G Carlton et al. Nat Rev Mol Cell Biol. 2020 Mar.

. 2020 Mar;21(3):151-166.

doi: 10.1038/s41580-019-0208-1. Epub 2020 Feb 7.

Authors

Jeremy G Carlton^{1

2}, Hannah Jones^{3

4}, Ulrike S Eggert⁵

Affiliations

¹ School of Cancer and Pharmaceutical Sciences, King's College London, London, UK. jeremy.carlton@kcl.ac.uk.
² The Francis Crick Institute, London, UK. jeremy.carlton@kcl.ac.uk.
³ School of Cancer and Pharmaceutical Sciences, King's College London, London, UK.
⁴ The Francis Crick Institute, London, UK.
⁵ Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences and Department of Chemistry, King's College London, London, UK. ulrike.eggert@kcl.ac.uk.

PMID: 32034394
DOI: 10.1038/s41580-019-0208-1

Abstract

During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling of their cytoskeleton and membranes. For cell division to occur, chromosomes must be segregated and new cellular structures, such as the spindle apparatus, must be assembled. Pre-existing organelles, such as the nuclear envelope, endoplasmic reticulum and Golgi apparatus, must be disassembled or remodelled, distributed and reformed. Smaller organelles such as mitochondria as well as cytoplasmic content must also be properly distributed between daughter cells. This mixture of organelles and cytoplasm is bound by a plasma membrane that is itself subject to remodelling as division progresses. The lipids resident in these different membrane compartments play important roles in facilitating the division process. In recent years, we have begun to understand how membrane remodelling is coordinated during division; however, there is still much to learn. In this Review, we discuss recent insights into how these important cellular events are performed and regulated.

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References

1. Walczak, C. E., Cai, S. & Khodjakov, A. Mechanisms of chromosome behaviour during mitosis. Nat. Rev. Mol. Cell Biol. 11, 91–102 (2010). - PubMed - PMC
1. Green, R. A., Paluch, E. & Oegema, K. Cytokinesis in animal cells. Annu. Rev. Cell Dev. Biol. 28, 29–58 (2012). - PubMed
1. Mierzwa, B. & Gerlich, D. W. Cytokinetic abscission: molecular mechanisms and temporal control. Dev. Cell 31, 525–538 (2014). - PubMed
1. Mishra, P. & Chan, D. C. Mitochondrial dynamics and inheritance during cell division, development and disease. Nat. Rev. Mol. Cell Biol. 15, 634–646 (2014). - PubMed - PMC
1. Eggert, U. S. et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2, e379 (2004). - PubMed - PMC

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[1] Walczak, C. E., Cai, S. & Khodjakov, A. Mechanisms of chromosome behaviour during mitosis. Nat. Rev. Mol. Cell Biol. 11, 91–102 (2010). - PubMed - PMC

[2] Walczak, C. E., Cai, S. & Khodjakov, A. Mechanisms of chromosome behaviour during mitosis. Nat. Rev. Mol. Cell Biol. 11, 91–102 (2010). - PubMed - PMC

[3] Green, R. A., Paluch, E. & Oegema, K. Cytokinesis in animal cells. Annu. Rev. Cell Dev. Biol. 28, 29–58 (2012). - PubMed

[4] Green, R. A., Paluch, E. & Oegema, K. Cytokinesis in animal cells. Annu. Rev. Cell Dev. Biol. 28, 29–58 (2012). - PubMed

[5] Mierzwa, B. & Gerlich, D. W. Cytokinetic abscission: molecular mechanisms and temporal control. Dev. Cell 31, 525–538 (2014). - PubMed

[6] Mierzwa, B. & Gerlich, D. W. Cytokinetic abscission: molecular mechanisms and temporal control. Dev. Cell 31, 525–538 (2014). - PubMed

[7] Mishra, P. & Chan, D. C. Mitochondrial dynamics and inheritance during cell division, development and disease. Nat. Rev. Mol. Cell Biol. 15, 634–646 (2014). - PubMed - PMC

[8] Mishra, P. & Chan, D. C. Mitochondrial dynamics and inheritance during cell division, development and disease. Nat. Rev. Mol. Cell Biol. 15, 634–646 (2014). - PubMed - PMC

[9] Eggert, U. S. et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2, e379 (2004). - PubMed - PMC

[10] Eggert, U. S. et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2, e379 (2004). - PubMed - PMC

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Membrane and organelle dynamics during cell division

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Membrane and organelle dynamics during cell division

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