Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar:83:35-47.
doi: 10.1016/j.exphem.2020.01.009. Epub 2020 Jan 30.

Clones assemble! The clonal complexity of blood during ontogeny and disease

Miguel Ganuza  1 , Trent Hall  1 , Esther A Obeng  2 , Shannon McKinney-Freeman  3
Affiliations
Review

Clones assemble! The clonal complexity of blood during ontogeny and disease

Miguel Ganuza et al. Exp Hematol. 2020 Mar.

Abstract

Hematopoietic stem and progenitor cells (HSPCs) govern the daily expansion and turnover of billions of specialized blood cells. Given their clinical utility, much effort has been made toward understanding the dynamics of hematopoietic production from this pool of stem cells. An understanding of hematopoietic stem cell clonal dynamics during blood ontogeny could yield important insights into hematopoietic regulation, especially during aging and repeated exposure to hematopoietic stress-insults that may predispose individuals to the development of hematopoietic disease. Here, we review the current state of research regarding the clonal complexity of the hematopoietic system during embryogenesis, adulthood, and hematologic disease.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ng AP & Alexander WS Haematopoietic stem cells: past, present and future. Cell Death Discov 3, 17002, doi:10.1038/cddiscovery.2017.2 (2017). - DOI - PMC - PubMed
    1. Laurenti E & Gottgens B From haematopoietic stem cells to complex differentiation landscapes. Nature 553, 418–426, doi:10.1038/nature25022 (2018). - DOI - PMC - PubMed
    1. Medvinsky A, Rybtsov S & Taoudi S Embryonic origin of the adult hematopoietic system: advances and questions. Development 138, 1017–1031, doi:10.1242/dev.040998 (2011). - DOI - PubMed
    1. Mikkola HK & Orkin SH The journey of developing hematopoietic stem cells. Development 133, 3733–3744, doi:10.1242/dev.02568 (2006). - DOI - PubMed
    1. Bertrand JY & Traver D Hematopoietic cell development in the zebrafish embryo. Curr Opin Hematol 16, 243–248, doi:10.1097/MOH.0b013e32832c05e4 (2009). - DOI - PubMed

Publication types