Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 30;31(2):22.
doi: 10.1007/s10856-020-6361-4.

β-cyclodextrin coating: improving biocompatibility of magnetic nanocomposites for biomedical applications

Mariela Agotegaray  1 , María Gabriela Blanco  2 , Adrián Campelo  3 , Elba García  4 , Roberto Zysler  5 , Virginia Massheimer  3 , María José De Rosa  6 , Verónica Lassalle  4
Affiliations

β-cyclodextrin coating: improving biocompatibility of magnetic nanocomposites for biomedical applications

Mariela Agotegaray et al. J Mater Sci Mater Med. .

Abstract

The role Beta-cyclodextrin (βCD) on improving biocompatibility on healthy cellular and animal models was studied upon a formulation obtained from the development of a simple coating procedure. The obtained nanosystems were thoroughly characterized by FTIR, TGA, atomic absorption spectroscopy, dynamic light scattering and zeta potential, TEM/HR-TEM and magnetic properties. βCD might interact with the magnetic core through hosting OA. It is feasible that the nanocomposite is formed by nanoparticles of MG@OA dispersed in a βCD matrix. The evaluation of βCD role on biocompatibility was performed on two healthy models. To this end, in vivo studies were carried out on Caenorhabditis elegans. Locomotion and progeny were evaluated after exposure animals to MG, MG@OA, and MG@OA-βCD (10 to 500 µg/mL). The influence of βCD on cytotoxicity was explored in vitro on healthy rat aortic endothelial cells, avoiding alteration in the results derived from the use of transformed cell lines. Biological studies demonstrated that βCD attaching improves MG biocompatibility.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Int J Mol Sci. 2013 Oct 25;14(11):21266-305 - PubMed
    1. PLoS Negl Trop Dis. 2019 Nov 25;13(11):e0007895 - PubMed
    1. Nat Protoc. 2006;1(4):1772-7 - PubMed
    1. Acc Chem Res. 2014 Feb 18;47(2):667-77 - PubMed
    1. Biometals. 2010 Aug;23(4):623-32 - PubMed

LinkOut - more resources