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Review
. 2020 Jan 20;8(1):35.
doi: 10.3390/vaccines8010035.

Cytomegalovirus and Epstein-Barr Virus Associations with Neurological Diseases and the Need for Vaccine Development

Affiliations
Review

Cytomegalovirus and Epstein-Barr Virus Associations with Neurological Diseases and the Need for Vaccine Development

Peter A C Maple. Vaccines (Basel). .

Abstract

Herpesviruses have been isolated from a wide range of hosts including humans-for which, nine species have been designated. The human herpesviruses are highly host adapted and possess the capacity for latency, allowing them to survive in the host for life, effectively hidden from the immune system. This ability of human herpesviruses to modulate the host immune response poses particular challenges for vaccine development but at the same time proves attractive for the application of human herpesvirus vaccines to certain spheres of medicine. In this review, congenital cytomegalovirus (CMV) infection and hearing loss will be described followed by a comment on the status of current vaccine development. Secondly, the association of Epstein-Barr virus (EBV) infection with multiple sclerosis (MS) and how EBV vaccination may be of benefit will then be discussed. Prevention of congenital CMV by vaccination is an attractive proposition and several vaccines have been evaluated for potential use. Particularly challenging for the development of CMV vaccines are the needs to prevent primary infection, reinfection, and reactivation at the same time as overcoming the capacity of the virus to generate highly sophisticated immunomodulatory mechanisms. Cost and the practicalities of administering potential vaccines are also significant issues, particularly for low- and middle-income countries, where the burden of disease is greatest. An effective EBV vaccine that could prevent the 200,000 new EBV-associated malignancies which occur globally each year is not currently available. There is increasing interest in developing EBV vaccines to prevent MS and, in view of the association of infectious mononucleosis with MS, reducing childhood infectious mononucleosis is a potential intervention. Currently, there is no licensed EBV vaccine and, in order to progress the development of EBV vaccines for preventing MS, a greater understanding of the association of EBV with MS is required.

Keywords: Cytomegalovirus; Epstein–Barr virus; congenital infection; multiple sclerosis.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Virus Taxonomy: The Classification and Nomenclature of Viruses the Online (10th) Report of the ICTV. [(accessed on 20 December 2019)]; Available online: http://talk.ictvonline.org/ictv-reports/ictv_online_report/
    1. Chiesa M.D., De Maria A., Muccio L., Bozzano F., Sivori S., Moretta L. Human NK cells and herpesviruses: Mechanisms of recognition, response and adaptation. Front. Microbiol. 2019;10:2297. doi: 10.3389/fmicb.2019.02297. - DOI - PMC - PubMed
    1. Stevens J.G. Human herpesviruses: A consideration of the latent state. Microbiol. Rev. 1989;53:318–332. doi: 10.1128/MMBR.53.3.318-332.1989. - DOI - PMC - PubMed
    1. De Pelsmaeker S., Romero N., Vitale M., Favoreel H.W. Herpesvirus evasion of natural killer cells. J. Virol. 2018;92:e02105-17. doi: 10.1128/JVI.02105-17. - DOI - PMC - PubMed
    1. Goodier M.R., Jonjić S., Riley E.M., Lisnić V.J. CMV and natural killer cells: Shaping the response to vaccination. Eur. J. Immunol. 2018;48:50–65. doi: 10.1002/eji.201646762. - DOI - PubMed

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