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. 2017 Oct 1;10(10):10559-10564.
eCollection 2017.

CHI3L1 is correlated with childhood asthma

Feng Chen  1 , Yuan An  2 , Juan Wang  2
Affiliations

CHI3L1 is correlated with childhood asthma

Feng Chen et al. Int J Clin Exp Pathol. .

Abstract

Objective: The aim of this study was to assess the association between CHI3L1 gene two single nucleotide polymorphisms (SNPs) (rs12141494 and rs4950928) and susceptibility to pediatric asthma in a Chinese Han population.

Methods: The case-control study was carried out on 115 children with asthma and 108 healthy controls. Genotypes of rs12141494 and rs4950928 within CHI3L1 gene were determined with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) approach. Chi-square test was employed to analyze the differences of genotype and allele frequencies of the two polymorphisms between case and control groups. Odds ratios (ORs) and 95% confidence intervals (CIs) were applied to explain relative susceptibility of pediatric asthma.

Results: The frequencies of genotypes and alleles of rs4950928 in CHI3L1 gene showed a significant difference between asthmatic children and healthy controls (P<0.05). However, no significant differences were found in CHI3L1 SNP rs12141494 between two groups (P>0.05).

Conclusion: Our results suggested that rs4950928 in CHI3L1 gene was associated with pediatric asthma risk in a Chinese Han population, while rs12141494 was not.

Keywords: CHI3L1; PCR-RFLP; pediatric asthma; polymorphism.

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Conflict of interest statement

None.

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