Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Oct 1;255(1):223-8.

Extracellular superoxide dismutase in the vascular system of mammals

Affiliations

Extracellular superoxide dismutase in the vascular system of mammals

K Karlsson et al. Biochem J. .

Abstract

Plasma extracellular superoxide dismutase (EC-SOD) from the pig, cat, rabbit, guinea pig and mouse was found to be heterogeneous with regard to heparin affinity and could be separated into three fractions: A without affinity, B with weak affinity and C with relatively high affinity. Rat plasma EC-SOD was deviant and contained only A and B fractions. There were very large interspecies differences in total plasma EC-SOD activity and in division of the activity between the different fractions. Intravenous injection of heparin resulted in the pig, dog, cat, rabbit, guinea pig and mouse in a prompt increase in the plasma SOD activity. The increase was due to release of EC-SOD C to plasma, most probably from endothelial cell surfaces. In the rat, heparin induced no increase in plasma SOD activity, apparently because of the absence of EC-SOD C in this species. The relative heparin-induced increase in plasma EC-SOD C varied between 2 and 11 in the different species and was distinctly correlated with the heparin affinity of EC-SOD C in the particular species. Apparently the EC-SOD C, present in the vasculature, forms an equilibrium between plasma and endothelium, whereas EC-SOD A and B primarily exist in plasma. The wide diversity of EC-SOD in the vascular system of mammals with regard to total amount, division into fractions and distribution between plasma and endothelium indicates that the pathogenic potential of superoxide radicals in the extracellular space might vary much between species.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Biol Chem. 1976 Dec 10;251(23):7504-7 - PubMed
    1. J Lab Clin Med. 1960 Sep;56:486-98 - PubMed
    1. Proc Natl Acad Sci U S A. 1980 Feb;77(2):1159-63 - PubMed
    1. Thromb Res. 1980 Jul 1-15;19(1-2):129-37 - PubMed
    1. Am J Pathol. 1981 Jan;102(1):55-61 - PubMed

Publication types

LinkOut - more resources