Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb;25(1):101069.
doi: 10.1016/j.siny.2019.101069. Epub 2019 Dec 2.

History, epidemiology and prevalence of neonatal bone mineral metabolic disorders

Elizabeth V Schulz  1 , Carol L Wagner  2
Affiliations
Review

History, epidemiology and prevalence of neonatal bone mineral metabolic disorders

Elizabeth V Schulz et al. Semin Fetal Neonatal Med. 2020 Feb.

Abstract

The evolutionary patterns of human migration and historical pre/post-industrial revolution have changed the face of bone metabolic disease through past centuries. Cultural, religious, and lifestyle practices continue to alter nutritional recommendations for this expanding diagnosis. Likewise, modern advancements in the field of neonatology and, more specifically, aggressive nutritional management of premature infants have shaped the epidemiology of neonatal bone metabolism over the past two decades. Decreased use of long-term parenteral nutrition, early fortification of enteral nutrition, and stringent American Academy of Pediatrics (AAP) practice guidelines instituting early supplementation of vitamin D have attributed to improved bone mineralization outcomes in both term and preterm infants. Nevertheless, neonatal bone mineral metabolic disorders remain prevalent. In this review, we provide an in-depth look at the diagnoses, therapeutics, and subset populations-both genetic and non-genetic-affected by neonatal bone mineral metabolic disorders.

Keywords: Bone; Infant; Parenteral nutrition; Rickets; Vitamin D.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors have no disclosures or conflicts to declare.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles