Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul;40(4):1220-1275.
doi: 10.1002/med.21657. Epub 2020 Jan 12.

Artemisinin-derived antimalarial endoperoxides from bench-side to bed-side: Chronological advancements and future challenges

Mohit K Tiwari  1 , Sandeep Chaudhary  1
Affiliations
Review

Artemisinin-derived antimalarial endoperoxides from bench-side to bed-side: Chronological advancements and future challenges

Mohit K Tiwari et al. Med Res Rev. 2020 Jul.

Abstract

According to WHO World Malaria Report (2018), nearly 219 million new cases of malaria occurred and a total no. of 435 000 people died in 2017 due to this infectious disease. This is due to the rapid spread of parasite-resistant strains. Artemisinin (ART), a sesquiterpene lactone endoperoxide isolated from traditional Chinese herb Artemisia annua, has been recognized as a novel class of antimalarial drugs. The 2015 "Nobel Prize in Physiology or Medicine" was given to Prof Dr Tu Youyou for the discovery of ART. Hence, ART is termed as "Nobel medicine." The present review article accommodates insights from the chronological advancements and direct statistics witnessed during the past 48 years (1971-2019) in the medicinal chemistry of ART-derived antimalarial endoperoxides, and their clinical utility in malaria chemotherapy and drug discovery.

Keywords: antimalarial endoperoxides; arteether; artemether; artemisinin; artesunate; dihydroartemisinin; malaria; multidrug resistant.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Poinar G. Evolutionary history of terrestrial pathogens and endoparasites as revealed in fossils and subfossils. Adv Biol. 2014;2014:181353.
    1. Poinar GO. Culex malariager, n. sp. (Diptera: Culicidae) from Dominican amber: the first fossil mosquito vector of Plasmodium. Proc Entomol Soc Wash. 2005;107(3):548-181553.
    1. Poinar G. Plasmodium dominicana n. sp. (Plasmodiidae: Haemospororida) from Tertiary Dominican amber. Syst Parasitol. 2005;61(1):47-52.
    1. Carter R, Mendis KN. Evolutionary and historical aspects of the burden of malaria. Clin Microbiol Rev. 2002;15(4):564-594.
    1. Hempelmann E, Krafts K. Bad air, amulets and mosquitoes: 2,000 years of changing perspectives on malaria. Malar J. 2013;12(1):213.

Publication types

LinkOut - more resources