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Review
. 2020 Apr;48(4):300060519895347.
doi: 10.1177/0300060519895347. Epub 2019 Dec 29.

Advances in research on the interaction between inflammation and cancer

Xin-Da Song  1 , Ya-Ni Wang  2 , Ai-Li Zhang  3 , Bin Liu  3
Affiliations
Review

Advances in research on the interaction between inflammation and cancer

Xin-Da Song et al. J Int Med Res. 2020 Apr.

Abstract

Inflammation is the body's response to cell damage. Cancer is a general term that describes all malignant tumours. There are no confirmed data on cancer-related inflammation, but some research suggests that up to 50% of cancers may be linked to inflammation, which has led to the concept of 'cancer-associated inflammation'. Although some cancer patients do not appear to have a chronic inflammatory background, there might be inflammatory cell infiltration in their cancer tissues. The continuation of the inflammatory response plays an important role in the initiation, promotion, malignant transformation, invasion and metastasis of cancer. Anti-inflammatory therapy has been shown to have some effects on the prevention and treatment of cancer, which supports a pathogenic relationship between inflammation and cancer. This review describes the interaction between inflammation and tumour development and the main mechanism of regulation of the inflammatory response during tumour development.

Keywords: Inflammation; cancer; metastasis; microenvironment; prostate cancer; prostatitis.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

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References

    1. Liao CP, Booker RC, Brosseau JPet al. Contributions of inflammation and tumor microenvironment to neurofibroma tumorigenesis. J Clin Invest 2018; 128: 2848–2861. - PMC - PubMed
    1. Wang F, Meng W, Wang Bet al. Helicobacter pylori-induced gastric inflammation and gastric cancer. Cancer Lett 2014; 345: 196–202. - PubMed
    1. Hasche D, Stephan S, Braspenning-Wesch Iet al. The interplay of UV and cutaneous papillomavirus infection in skin cancer development. PLoS Pathog 2017; 13: e1006723. - PMC - PubMed
    1. Lund AW, Medler TR, Leachman SAet al. Lymphatic vessels, inflammation, and immunity in skin cancer. Cancer Discov 2016; 6: 22–35. - PMC - PubMed
    1. Ayers LW, Barbachano-Guerrero A, McAllister SCet al. Mast cell activation and KSHV infection in Kaposi sarcoma. Clin Cancer Res 2018; 24: 5085–5097. - PMC - PubMed

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