Immunity to Influenza Infection in Humans

doi:10.1101/cshperspect.a038729

Review

. 2021 Mar 1;11(3):a038729.

doi: 10.1101/cshperspect.a038729.

Immunity to Influenza Infection in Humans

David J Topham¹, Marta L DeDiego², Aitor Nogales³, Mark Y Sangster¹, Andrea Sant¹

Affiliations

¹ David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA.
² Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain.
³ Instituto Nacional de Investigación y Tecnologia Agraria y Ailmentaria, 28040 Madrid, Spain.

PMID: 31871226
PMCID: PMC7919402
DOI: 10.1101/cshperspect.a038729

Review

Immunity to Influenza Infection in Humans

David J Topham et al. Cold Spring Harb Perspect Med. 2021.

. 2021 Mar 1;11(3):a038729.

doi: 10.1101/cshperspect.a038729.

Authors

David J Topham¹, Marta L DeDiego², Aitor Nogales³, Mark Y Sangster¹, Andrea Sant¹

Affiliations

¹ David H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York 14642, USA.
² Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain.
³ Instituto Nacional de Investigación y Tecnologia Agraria y Ailmentaria, 28040 Madrid, Spain.

PMID: 31871226
PMCID: PMC7919402
DOI: 10.1101/cshperspect.a038729

Abstract

This review discusses the human immune responses to influenza infection with some insights from studies using animal models, such as experimental infection of mice. Recent technological advances in the study of human immune responses have greatly added to our knowledge of the infection and immune responses, and therefore much of the focus is on recent studies that have moved the field forward. We consider the complexity of the adaptive response generated by many sequential encounters through infection and vaccination.

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Flublok Quadrivalent Vaccine Adjuvanted with R-DOTAP Elicits a Robust and Multifunctional CD4 T Cell Response That Is of Greater Magnitude and Functional Diversity Than Conventional Adjuvant Systems.
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Nogales A, Steel J, Liu WC, Lowen AC, Rodriguez L, Chiem K, Cox A, García-Sastre A, Albrecht RA, Dewhurst S, Martínez-Sobrido L. Nogales A, et al. Microbiol Spectr. 2022 Jun 29;10(3):e0007822. doi: 10.1128/spectrum.00078-22. Epub 2022 May 18. Microbiol Spectr. 2022. PMID: 35583364 Free PMC article.
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References

1. Abelleira R, Ruano-Ravina A, Lama A, Barbeito G, Toubes ME, Domínguez-Antelo C, González-Barcala FJ, Rodríguez-Núñez N, Marcos PJ, Pérez Del Molino ML, et al. 2019. Influenza A H1N1 community-acquired pneumonia: characteristics and risk factors—a case-control study. Can Respir J 2019: 4301039. 10.1155/2019/4301039 - DOI - PMC - PubMed
1. Ahrends T, Spanjaard A, Pilzecker B, Bąbała N, Bovens A, Xiao Y, Jacobs H, Borst J. 2017. CD4+ T cell help confers a cytotoxic T cell effector program including coinhibitory receptor downregulation and increased tissue invasiveness. Immunity 47: 848–861.e5. 10.1016/j.immuni.2017.10.009 - DOI - PubMed
1. Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue-Sawano A, Tomura M, Luche H, Fehling HJ, Casellas R, Kanagawa O, et al. 2010. Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci 107: 12192–12197. 10.1073/pnas.1005443107 - DOI - PMC - PubMed
1. Alam S, Sant AJ. 2011. Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus. J Virol 85: 13310–13321. 10.1128/JVI.05728-11 - DOI - PMC - PubMed
1. Alam S, Knowlden ZA, Sangster MY, Sant AJ. 2014. CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection. J Virol 88: 314–324. 10.1128/JVI.02077-13 - DOI - PMC - PubMed

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[1] Abelleira R, Ruano-Ravina A, Lama A, Barbeito G, Toubes ME, Domínguez-Antelo C, González-Barcala FJ, Rodríguez-Núñez N, Marcos PJ, Pérez Del Molino ML, et al. 2019. Influenza A H1N1 community-acquired pneumonia: characteristics and risk factors—a case-control study. Can Respir J 2019: 4301039. 10.1155/2019/4301039 - DOI - PMC - PubMed

[2] Abelleira R, Ruano-Ravina A, Lama A, Barbeito G, Toubes ME, Domínguez-Antelo C, González-Barcala FJ, Rodríguez-Núñez N, Marcos PJ, Pérez Del Molino ML, et al. 2019. Influenza A H1N1 community-acquired pneumonia: characteristics and risk factors—a case-control study. Can Respir J 2019: 4301039. 10.1155/2019/4301039 - DOI - PMC - PubMed

[3] Ahrends T, Spanjaard A, Pilzecker B, Bąbała N, Bovens A, Xiao Y, Jacobs H, Borst J. 2017. CD4+ T cell help confers a cytotoxic T cell effector program including coinhibitory receptor downregulation and increased tissue invasiveness. Immunity 47: 848–861.e5. 10.1016/j.immuni.2017.10.009 - DOI - PubMed

[4] Ahrends T, Spanjaard A, Pilzecker B, Bąbała N, Bovens A, Xiao Y, Jacobs H, Borst J. 2017. CD4+ T cell help confers a cytotoxic T cell effector program including coinhibitory receptor downregulation and increased tissue invasiveness. Immunity 47: 848–861.e5. 10.1016/j.immuni.2017.10.009 - DOI - PubMed

[5] Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue-Sawano A, Tomura M, Luche H, Fehling HJ, Casellas R, Kanagawa O, et al. 2010. Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci 107: 12192–12197. 10.1073/pnas.1005443107 - DOI - PMC - PubMed

[6] Aiba Y, Kometani K, Hamadate M, Moriyama S, Sakaue-Sawano A, Tomura M, Luche H, Fehling HJ, Casellas R, Kanagawa O, et al. 2010. Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci 107: 12192–12197. 10.1073/pnas.1005443107 - DOI - PMC - PubMed

[7] Alam S, Sant AJ. 2011. Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus. J Virol 85: 13310–13321. 10.1128/JVI.05728-11 - DOI - PMC - PubMed

[8] Alam S, Sant AJ. 2011. Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus. J Virol 85: 13310–13321. 10.1128/JVI.05728-11 - DOI - PMC - PubMed

[9] Alam S, Knowlden ZA, Sangster MY, Sant AJ. 2014. CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection. J Virol 88: 314–324. 10.1128/JVI.02077-13 - DOI - PMC - PubMed

[10] Alam S, Knowlden ZA, Sangster MY, Sant AJ. 2014. CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection. J Virol 88: 314–324. 10.1128/JVI.02077-13 - DOI - PMC - PubMed

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Immunity to Influenza Infection in Humans

Affiliations

Immunity to Influenza Infection in Humans

Authors

Affiliations

Abstract

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Grants and funding

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Medical