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Review
. 2020 Apr;17(2):405-418.
doi: 10.1111/iwj.13286. Epub 2019 Dec 20.

Biological approaches for hypertrophic scars

Zhong Lingzhi  1 , Li Meirong  1   2 , Fu Xiaobing  1
Affiliations
Review

Biological approaches for hypertrophic scars

Zhong Lingzhi et al. Int Wound J. 2020 Apr.

Abstract

Scar formation is usually the pathological consequence of skin trauma. And hypertrophic scars (HSs) frequently occur in people after being injured deeply. HSs are unusually considered as the result of tissue contraction and excessive extracellular matrix component deposition. Myofibroblasts, as the effector cells, mainly differentiated from fibroblasts, play the crucial role in the pathophysiology of HSs. A number of growth factors, inflammatory cytokines involved in the process of HS occurrence. Currently, with in-depth exploration and clinical research of HSs, various creative and effective treatments budded. In here, we summarize the progress in the molecular mechanism of HSs, and review the available biotherapeutic methods for their pathophysiological characteristics. Additionally, we further prospected that the comprehensive therapy may be more suitable for HS treatment.

Keywords: MSC; biological strategies; hypertrophic scar; prevention; wound healing.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

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