Organoids in immunological research

doi:10.1038/s41577-019-0248-y

Review

. 2020 May;20(5):279-293.

doi: 10.1038/s41577-019-0248-y. Epub 2019 Dec 18.

Organoids in immunological research

Yotam E Bar-Ephraim^#¹, Kai Kretzschmar^#¹, Hans Clevers^{2

3}

Affiliations

¹ Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands.
² Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands. h.clevers@hubrecht.eu.
³ Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. h.clevers@hubrecht.eu.

^# Contributed equally.

PMID: 31853049
DOI: 10.1038/s41577-019-0248-y

Review

Organoids in immunological research

Yotam E Bar-Ephraim et al. Nat Rev Immunol. 2020 May.

. 2020 May;20(5):279-293.

doi: 10.1038/s41577-019-0248-y. Epub 2019 Dec 18.

Authors

Yotam E Bar-Ephraim^#¹, Kai Kretzschmar^#¹, Hans Clevers^{2

3}

Affiliations

¹ Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands.
² Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands. h.clevers@hubrecht.eu.
³ Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands. h.clevers@hubrecht.eu.

^# Contributed equally.

PMID: 31853049
DOI: 10.1038/s41577-019-0248-y

Abstract

Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and co-cultures with cell lines. However, unique features of human cells cannot be modelled in mice, and cell lines are often transformed or genetically immortalized. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state. In this Review, we discuss how organoids are being used in immunological research to understand the role of epithelial cell-immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer.

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References

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[1] Ganusov, V. V. & De Boer, R. J. Do most lymphocytes in humans really reside in the gut? Trends Immunol. 28, 514–518 (2007). - PubMed - DOI

[2] Ganusov, V. V. & De Boer, R. J. Do most lymphocytes in humans really reside in the gut? Trends Immunol. 28, 514–518 (2007). - PubMed - DOI

[3] Kobayashi, T., Naik, S. & Nagao, K. Choreographing immunity in the skin epithelial barrier. Immunity 50, 552–565 (2019). - PubMed - PMC - DOI

[4] Kobayashi, T., Naik, S. & Nagao, K. Choreographing immunity in the skin epithelial barrier. Immunity 50, 552–565 (2019). - PubMed - PMC - DOI

[5] McNamara, H. A. & Cockburn, I. A. The three Rs: recruitment, retention and residence of leukocytes in the liver. Clin. Transl Immunology 5, e123 (2016). - PubMed - PMC - DOI

[6] McNamara, H. A. & Cockburn, I. A. The three Rs: recruitment, retention and residence of leukocytes in the liver. Clin. Transl Immunology 5, e123 (2016). - PubMed - PMC - DOI

[7] Rankin, L. C. & Artis, D. Beyond host defense: emerging functions of the immune system in regulating complex tissue physiology. Cell 173, 554–567 (2018). - PubMed - DOI

[8] Rankin, L. C. & Artis, D. Beyond host defense: emerging functions of the immune system in regulating complex tissue physiology. Cell 173, 554–567 (2018). - PubMed - DOI

[9] Mowat, A. M. & Agace, W. W. Regional specialization within the intestinal immune system. Nat. Rev. Immunol. 14, 667–685 (2014). - PubMed - DOI

[10] Mowat, A. M. & Agace, W. W. Regional specialization within the intestinal immune system. Nat. Rev. Immunol. 14, 667–685 (2014). - PubMed - DOI

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Organoids in immunological research

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Organoids in immunological research

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