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. 2019 Nov 11:2019:7510315.
doi: 10.1155/2019/7510315. eCollection 2019.

Short Communication: Interaction of Nerve Growth Factor (NGF) and Vascular Endothelial Growth Factor (VEGF) in Healthy Individuals

Adrian Groh  1 , Kirsten Jahn  1 , Michael Gröschl  2 , Thomas Hillemacher  1   3 , Johannes Kornhuber  4 , Stefan Bleich  1 , Helge Frieling  1 , Annemarie Heberlein  1
Affiliations

Short Communication: Interaction of Nerve Growth Factor (NGF) and Vascular Endothelial Growth Factor (VEGF) in Healthy Individuals

Adrian Groh et al. Dis Markers. .

Abstract

NGF and VEGF are known to be involved in different psychiatric diseases. In order to verify hints from basic research that both neurotrophines interact with each other, serum levels of NGF and VEGF were measured in a cohort of 33 healthy individuals and correlated. NGF level was 126.30 pg/mL (±155.43), and VEGF level was 57.28 pg/mL (±44.48). Both factors were significantly correlated, confirming their interaction and legitimising the usage of their respective ratio (0.8 (±0.42)) as a less varying additional marker in prospective studies.

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Conflict of interest statement

None of the authors has a financial or personal conflict of interest.

Figures

Figure 1
Figure 1
(a) The serum concentration of NGF and VEGF in pg/mL. (b) The correlation of NGF and VEGF values (pg/mL) as indicated by the regression line. (c) The ratio of the NEGF and VEGF serum concentration.
See this image and copyright information in PMC

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