Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Dec 10;5(1):194.
doi: 10.1186/s40792-019-0752-0.

Primary peritoneal carcinoma with late-phase pulmonary metastases: a case report

Naoki Ozeki  1 , Shuhei Hakiri  2 , Hisashi Tateyama  3 , Kohei Yokoi  2 , Toyofumi Chen-Yoshikawa  2
Affiliations

Primary peritoneal carcinoma with late-phase pulmonary metastases: a case report

Naoki Ozeki et al. Surg Case Rep. .

Abstract

Background: Primary peritoneal carcinoma (PPC) is a very rare and aggressive type of malignancy with a poor prognosis.

Case presentation: A 66-year-old woman was referred to our hospital with two pulmonary nodules that developed after PPC resection and postoperative adjuvant chemotherapy administered 5 years earlier. Computed tomography revealed a 1.3-cm-sized nodule in the left lung with a small airspace in the posterior basal segment and a 0.9-cm-sized solid nodule in the apico-posterior segment that grew slightly within a 2-month period. 18F-Fluorodeoxyglucose-positron emission tomography of these lesions revealed respective maximum standardized uptake values of 7.11 and 2.46. Her serum cancer antigen-125 level remained within the normal range, despite elevation before the first surgery. The posterior basal segment and superior division were subjected to anatomical segmentectomy. An intraoperative frozen section examination could not distinguish metastatic PPC from primary lung cancer. Immunopathologically, the two nodules were identified as metastatic PPC.

Conclusions: Our findings suggest that PPC patients may develop late-phase thoracic recurrence that is difficult to diagnose clinically after initial treatment in a potentially resectable setting.

Keywords: Fallopian tube carcinoma; Lung; Metastasis; Peritoneal carcinoma.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Contrast-enhanced computed tomography showing a pelvic peritoneal mass with irregular enhancement in the neighboring ileum and rectum. Ovaries and regional lymph nodes were not involved (a). Histological examination revealed irregular clusters of malignant cells with slit-like glandular spaces (magnification × 200) (b). Immunohistochemically, the tumor was positive for Wilms tumor-1 (× 200) (c)
Fig. 2
Fig. 2
Chest computed tomography showing a 1.3-cm-sized nodule with small airspace in the left posterior basal segment (a) and a 0.9-cm-sized solid nodule in the left apico-posterior segment (b). A histologic examination of the resected lung specimen resembling the previous primary peritoneal carcinoma. Irregular clusters of malignant cells with slit-like glandular spaces were observed. The tumor cells contained atypical large nuclei, prominent nucleoli, and frequent mitoses (× 200) (c)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Nik NN, Vang R, IeM S, Kurman RJ. Origin and pathogenesis of pelvic (ovarian, tubal, and primary peritoneal) serous carcinoma. Annu Rev Pathol. 2014;9:27–45. doi: 10.1146/annurev-pathol-020712-163949. - DOI - PubMed
    1. Katabathina VS, Amanullah FS, Menias CO, Chen MM, Valente PT, Chintapalli KN, et al. Extrauterine pelvic serous carcinomas: current update on pathology and cross-sectional imaging findings. Radiographics. 2016;36:918–932. doi: 10.1148/rg.2016150130. - DOI - PubMed
    1. Eltabbakh GH, Werness BA, Piver S, Blumenson LE. Prognostic factors in extraovarian primary peritoneal carcinoma. Gynecol Oncol. 1998;71:230–239. doi: 10.1006/gyno.1998.5090. - DOI - PubMed
    1. Landreneau RJ, Normolle DP, Christie NA, Awais O, Wizorek JJ, Abbas G, et al. Recurrence and survival outcomes after anatomic segmentectomy versus lobectomy for clinical stage I non-small-cell lung cancer: a propensity-matched analysis. J Clin Oncol. 2014;32:2449–2455. doi: 10.1200/JCO.2013.50.8762. - DOI - PMC - PubMed
    1. Martínez-Jiménez S, Rosado-de-Christenson ML, Walker CM, Kunin JR, Betancourt SL, Shoup BL, Pettavel PP. Imaging features of thoracic metastases from gynecologic neoplasms. Radiographics. 2014;34:1742–1754. doi: 10.1148/rg.346140052. - DOI - PubMed

LinkOut - more resources