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. 2019 Nov 21:12:221-228.
doi: 10.2147/TACG.S226664. eCollection 2019.

Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case-Control Study

Laith N Al-Eitan  1   2 , Rawan O Al Momani  1 , Khalid K Al Momani  3 , Ahmad M Al Warawrah  3 , Hanan A Aljamal  1 , Mansour A Alghamdi  4 , Alsharif M Muhanna  3 , Firas A Al-Qarqaz  5   6
Affiliations

Candidate Gene Analysis Of Alopecia Areata In Jordanian Population Of Arab Descent: A Case-Control Study

Laith N Al-Eitan et al. Appl Clin Genet. .

Abstract

Background: Alopecia areata (AA) is a non-cicatricial patchy hair loss on the scalp, face or other parts of the body. AA was found to be responsive to immunosuppressive therapies, a finding that supports an autoimmune basis for the disease. Several genetic studies have shown the significance of immunological factors as key genetic components in AA.

Objective: In this study, we aimed to investigate the genetic association of 7 single-nucleotide polymorphisms (SNPs) within five candidate genes including TAP1, CXCL1, CXCL2, HSPA1B, and TNFα with AA susceptibility in the Jordanian Arab population.

Methods: A case-control genetic association study conducted in 152 patients and 150 healthy individuals was performed using the sequenom MassARRAY system (iPLEX GOLD) to genotype the selected SNPs.

Results: rs1800629 SNP of the TNFα gene was significantly associated with AA in the heterozygous and rare homozygous genotypes (P=0.022 and P=0.0079, respectively) with no linkage of the TAP1, CXCL1, CXCL2 and HSPA1B variants.

Conclusion: This is the first study of its kind among the Jordanian population providing evidence of genetic association of the TNFα with AA susceptibility. Further genetic studies on Arab descent including other variants are required to clarify and strengthen the association of these genes with susceptibility to develop AA.

Keywords: CXCL1; CXCL2; Jordan; TAP1; alopecia areata; genetic association studies; immunological factors.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Representative scatter plot of rs1800629 SNP within the TNFα gene from sequenom data. The X and Y denote the mass height measurement for the two alleles. Green color (GG) genotype; yellow color (GA) genotype, blue color (AA) genotype, and red color denotes no call (n= 302).
See this image and copyright information in PMC

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Grants and funding

This work was supported by the Deanship of Research at Jordan University of Science and Technology under grant number (RN: 104/2017).