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Practice Guideline
. 2020 Feb;71(2):686-721.
doi: 10.1002/hep.31060.

Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection

Marc G Ghany  1 , Timothy R Morgan  2 ; AASLD-IDSA Hepatitis C Guidance Panel
Affiliations
Practice Guideline

Hepatitis C Guidance 2019 Update: American Association for the Study of Liver Diseases-Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection

Marc G Ghany et al. Hepatology. 2020 Feb.
No abstract available

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Figures

Figure 1.
Figure 1.. Recommended Testing for Diagnosis of Current HCV Infection or Reinfection
a For diagnosis of current initial HCV infection, begin with HCV-antibody testing. b For recurrent HCV infection, begin with HCV-RNA testing. c For persons who might have been exposed to HCV within the past 6 months, testing for HCV RNA or follow-up testing for HCV antibody should be performed. For persons who are immunocompromised, testing for HCV RNA should be performed. d To differentiate past, resolved HCV infection from biologic false positivity for HCV antibody, testing with another HCV-antibody assay can be considered. Repeat HCV-RNA testing if the person tested is suspected to have had HCV exposure within the past 6 months or has clinical evidence of HCV disease, or if there is concern regarding the handling or storage of the test specimen. Adapted from Centers for Disease Control and Prevention.(51)
Figure 2.
Figure 2.
Recommended Simplified HCV Treatment Algorithm for Treatment-Naive Adults Without Cirrhosis
Figure 3.
Figure 3.
Recommended Simplified HCV Treatment Algorithm for Treatment-Naive Adults With Compensated Cirrhosis
Figure 4.
Figure 4.. Testing Algorithm for Discrete, Recognized HCV Exposurea
a Often there is no discrete exposure and/or the entry to healthcare occurs with jaundice or elevated liver enzymes. In those instances, baseline testing cannot be performed and the diagnosis of acute HCV infection is based on clinical criteria (see text). b Repeat HCV Ab is not needed if the test is positive at baseline. Frequency of testing can be tailored based on risk of exposure. c If there were additional exposures in the preceding 6 months, a newly diagnosed patient who is HCV RNA and HCV Ab positive may still be in the acute phase. Symptoms, elevated ALT, and/or fluctuations in virus levels may distinguish acute from chronic HCV infection. d Baseline testing should be performed within 48 hours of exposure to determine existing infection status, including HCV RNA, HCV Ab, and ALT.
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