Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan;20(1):57-70.
doi: 10.1038/s41568-019-0226-5. Epub 2019 Dec 5.

Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets

Junfeng Bi  1 , Sudhir Chowdhry  1 , Sihan Wu  1 , Wenjing Zhang  1 , Kenta Masui  2 , Paul S Mischel  3   4   5
Affiliations
Review

Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets

Junfeng Bi et al. Nat Rev Cancer. 2020 Jan.

Abstract

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent technological advances, new insights into the molecular mechanisms underlying glioma metabolism are rapidly emerging. In this Review, we focus on the dynamic nature of glioma metabolism and how it is shaped by the interaction between tumour genotype and brain microenvironment. Recent advances integrating metabolomics with genomics are discussed, yielding new insight into the mechanisms that drive glioma pathogenesis. Studies that shed light on interactions between the tumour microenvironment and tumour genotype are highlighted, providing important clues as to how gliomas respond to and adapt to their changing tissue and biochemical contexts. Finally, a road map for the discovery of potential new glioma drug targets is suggested, with the goal of translating these new insights about glioma metabolism into clinical benefits for patients.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Sanai, N., Alvarez-Buylla, A. & Berger, M. S. Neural stem cells and the origin of gliomas. N. Engl. J. Med. 353, 811–822 (2005). - PubMed - DOI - PMC
    1. Weller, M. et al. Glioma. Nat. Rev. Dis. Prim. 1, 15017 (2015). - PubMed - DOI - PMC
    1. Cloughesy, T. F., Cavenee, W. K. & Mischel, P. S. Glioblastoma: from molecular pathology to targeted treatment. Annu. Rev. Pathol. 9, 1–25 (2014). - PubMed - DOI - PMC
    1. Brennan, C. W. et al. The somatic genomic landscape of glioblastoma. Cell 155, 462–477 (2013). - PubMed - PMC - DOI
    1. Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807–1812 (2008). - PubMed - PMC - DOI

Publication types

MeSH terms

LinkOut - more resources