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Review
. 2019 Nov;146(5):3692.
doi: 10.1121/1.5132553.

The rat animal model for noise-induced hearing loss

Celia D Escabi  1 , Mitchell D Frye  1 , Monica Trevino  1 , Edward Lobarinas  1
Affiliations
Review

The rat animal model for noise-induced hearing loss

Celia D Escabi et al. J Acoust Soc Am. 2019 Nov.

Abstract

Rats make excellent models for the study of medical, biological, genetic, and behavioral phenomena given their adaptability, robustness, survivability, and intelligence. The rat's general anatomy and physiology of the auditory system is similar to that observed in humans, and this has led to their use for investigating the effect of noise overexposure on the mammalian auditory system. The current paper provides a review of the rat model for studying noise-induced hearing loss and highlights advancements that have been made using the rat, particularly as these pertain to noise dose and the hazardous effects of different experimental noise types. In addition to the traditional loss of auditory function following acoustic trauma, recent findings have indicated the rat as a useful model in observing alterations in neuronal processing within the central nervous system following noise injury. Furthermore, the rat provides a second animal model when investigating noise-induced cochlear synaptopathy, as studies examining this in the rat model resemble the general patterns observed in mice. Together, these findings demonstrate the relevance of this animal model for furthering the authors' understanding of the effects of noise on structural, anatomical, physiological, and perceptual aspects of hearing.

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Figures

FIG. 1.
FIG. 1.
(Color online) Human cochlea and temporal bone from a de-identified cadaver gifted to the UT Southwestern Medical Center Willed Body Program is shown on the left. Sprague Dawley rat cochlea and temporal bone is shown on the right. White bar scale is 10 mm.
See this image and copyright information in PMC

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