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Review
. 2019 Dec;593(24):3649-3659.
doi: 10.1002/1873-3468.13699. Epub 2019 Dec 6.

Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host

Silvio Hemmi  1 , Katherine R Spindler  2
Affiliations
Review

Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host

Silvio Hemmi et al. FEBS Lett. 2019 Dec.

Abstract

Small laboratory animals are powerful models for investigating in vivo viral pathogenesis of a number of viruses. For adenoviruses (AdVs), however, species-specificity poses limitations to studying human adenoviruses (HAdVs) in mice and other small laboratory animals. Thus, this review covers work on naturally occurring mouse AdVs, primarily mouse adenovirus type 1 (MAdV-1), a member of the species Murine mastadenovirus A. Molecular genetics, virus life cycle, cell and tissue tropism, interactions with the host immune response, persistence, and host genetics of susceptibility are described. A brief discussion of MAdV-2 (member of species Murine mastadenovirus B) and MAdV-3 (member of species Murine mastadenovirus C) is included. We report the use of MAdVs in the development of vectors and vaccines.

Keywords: Ly6; PKR; adenovirus vaccines; adenovirus vectors; alpha-defensins; host susceptibility to viruses; immunoproteasome; mouse adenovirus; viral pathogenesis.

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