Perspectives, issues and solutions in RNAi therapy: the expected and the less expected
- PMID: 31752594
- DOI: 10.2217/nnm-2019-0321
Perspectives, issues and solutions in RNAi therapy: the expected and the less expected
Keywords: RNAi; clinical translation; delivery; nanocarrier; siRNA; siRNA target identification.
Similar articles
-
Recent advances in exosome-based nanovehicles as RNA interference therapeutic carriers.Nanomedicine (Lond). 2017 Nov;12(21):2653-2675. doi: 10.2217/nnm-2017-0210. Epub 2017 Sep 29. Nanomedicine (Lond). 2017. PMID: 28960165 Review.
-
Overcoming cellular barriers for RNA therapeutics.Nat Biotechnol. 2017 Mar;35(3):222-229. doi: 10.1038/nbt.3802. Epub 2017 Feb 27. Nat Biotechnol. 2017. PMID: 28244992 Review.
-
Development of siRNA Therapeutics for the Treatment of Liver Diseases.Methods Mol Biol. 2021;2282:57-75. doi: 10.1007/978-1-0716-1298-9_5. Methods Mol Biol. 2021. PMID: 33928570 Review.
-
siRNA therapeutics: a clinical reality.Sci China Life Sci. 2020 Apr;63(4):485-500. doi: 10.1007/s11427-018-9438-y. Epub 2019 Apr 30. Sci China Life Sci. 2020. PMID: 31054052 Review.
-
Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma.World J Gastroenterol. 2015 Nov 14;21(42):12022-41. doi: 10.3748/wjg.v21.i42.12022. World J Gastroenterol. 2015. PMID: 26576089 Free PMC article. Review.
Cited by
-
Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia.Front Mol Neurosci. 2022 Oct 13;15:1043947. doi: 10.3389/fnmol.2022.1043947. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36311034 Free PMC article. Review.
-
Lipid nanoparticle encapsulated large peritoneal macrophages migrate to the lungs via the systemic circulation in a model of clodronate-mediated lung-resident macrophage depletion.Theranostics. 2024 Apr 8;14(6):2526-2543. doi: 10.7150/thno.91062. eCollection 2024. Theranostics. 2024. PMID: 38646640 Free PMC article.
-
Nanotechnology-based gene therapy as a credible tool in the treatment of Alzheimer's disease.Neural Regen Res. 2023 Oct;18(10):2127-2133. doi: 10.4103/1673-5374.369096. Neural Regen Res. 2023. PMID: 37056119 Free PMC article. Review.
-
Emerging roles of RNA-binding proteins in fatty liver disease.Wiley Interdiscip Rev RNA. 2024 Mar-Apr;15(2):e1840. doi: 10.1002/wrna.1840. Wiley Interdiscip Rev RNA. 2024. PMID: 38613185 Review.
-
Analyzing siRNA Concentration, Complexation and Stability in Cationic Dendriplexes by Stem-Loop Reverse Transcription-qPCR.Pharmaceutics. 2022 Jun 25;14(7):1348. doi: 10.3390/pharmaceutics14071348. Pharmaceutics. 2022. PMID: 35890243 Free PMC article.
Publication types
MeSH terms
Substances
Supplementary concepts
LinkOut - more resources
Full Text Sources