Can PD-L1 tumor proportion score be used as the key to unlocking the KEYNOTE studies of pembrolizumab in advanced lung cancer?
- PMID: 31737509
- PMCID: PMC6835108
- DOI: 10.21037/tlcr.2019.05.12
Can PD-L1 tumor proportion score be used as the key to unlocking the KEYNOTE studies of pembrolizumab in advanced lung cancer?
Conflict of interest statement
Conflicts of Interest: D Rangachari reports non-financial support (institutional research support) from Bristol-Myers Squibb, Novocure, and Abbvie/Stemcentrx; all outside the submitted work. DB Costa reports personal fees (consulting fees and honoraria) and non-financial support (institutional research support) from Takeda/Millennium Pharmaceuticals, personal fees (consulting fees) and non-financial support (institutional research support) from AstraZeneca, personal fees (honoraria) and non-financial support (institutional research support) from Pfizer, non-financial support (institutional research support) from Merck Sharp & Dohme Corporation, non-financial support (institutional research support) from Merrimack Pharmaceuticals, non-financial support (institutional research support) from Bristol-Myers Squibb, non-financial support (institutional research support) from Clovis Oncology, non-financial support (institutional research support) from Tesaro; all outside the submitted work. The other authors have no conflicts of interest to declare.
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Comment on
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Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater.J Clin Oncol. 2019 Mar 1;37(7):537-546. doi: 10.1200/JCO.18.00149. Epub 2019 Jan 8. J Clin Oncol. 2019. PMID: 30620668 Clinical Trial.
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