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. 2019 Oct 11:10:687.
doi: 10.3389/fendo.2019.00687. eCollection 2019.

Osteocalcin Levels in Male Idiopathic Hypogonadotropic Hypogonadism: Relationship With the Testosterone Secretion and Metabolic Profiles

Yu-Ying Yang  1 , Si-Chang Zheng  1 , Wen-Cui Wang  1 , Zu-Wei Yang  1 , Chang Shan  1 , Yu-Wen Zhang  2 , Yan Qi  2 , Yu-Hong Chen  1   2 , Wei-Qiong Gu  1 , Wei-Qing Wang  1 , Hong-Yan Zhao  1 , Jian-Min Liu  1 , Shou-Yue Sun  1   2
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Osteocalcin Levels in Male Idiopathic Hypogonadotropic Hypogonadism: Relationship With the Testosterone Secretion and Metabolic Profiles

Yu-Ying Yang et al. Front Endocrinol (Lausanne). .

Abstract

Idiopathic hypogonadotropic hypogonadism (IHH) patients are characterized by the absence of puberty and varying degrees of deteriorated metabolic conditions. Osteocalcin (OC) could regulate testosterone secretion and energy metabolism, but it remains unknown whether such an effect exists in IHH patients. Our study is aimed to examine the relationship between serum OC levels with testosterone and its responsiveness to gonadotropin stimulation and metabolic profiles in male IHH patients. A total of 99 male patients aged 18-37 years and diagnosed with IHH were enrolled in the current study, and the relationships between OC and testicular volume, baseline total testosterone (TT), free testosterone (FT), and peak TT (Tmax) levels after human chorionic gonadotropin (hCG) stimulation, gonadotropin responsiveness index (GRI), which is calculated by dividing Tmax by testicular volume, as well as metabolic profiles, such as 2-h post-challenge glucose (2hPG) and fat percentage (fat%), were analyzed. The results showed that OC had an independent negative relationship with testicular volume (r = -0.253, P = 0.012) and a positive association with Tmax (r = 0.262, P = 0.014) after adjusting for confounders. In addition, OC was a major determinant of GRI (adjusted R 2 for the model = 0.164, P = 0.012), fat% (adjusted R 2 for the model = 0.100, P = 0.004), and 2hPG (adjusted R 2 for the model = 0.054, P = 0.013) in IHH patients. In conclusion, OC is associated with testosterone secretion upon gonadotropin stimulation, glucose metabolism, and fat mass variations in IHH. This study was registered at clinicaltrials.gov (NCT02310074).

Keywords: gonadotropin; idiopathic hypogonadotropic hypogonadism; metabolism; osteocalcin; testosterone.

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Figures

Figure 1
Figure 1
(A) The simple correlation between OC and testicular volume. (B) Partial correlation between OC and Tmax adjusted for age and testicular volume. The y-axis represents the residuals obtained after fitting a linear regression model using Tmax as a dependent variable, and age and testicular volume as the independent variables. The x-axis represents the residuals obtained after fitting a linear regression model using osteocalcin as a dependent variable, and age and testicular volume as the independent variables. (C) The simple correlation between OC and GRI.
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