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Observational Study
. 2020 Oct;160(4):926-935.e6.
doi: 10.1016/j.jtcvs.2019.08.130. Epub 2019 Sep 25.

Outcomes of different revascularization strategies among patients presenting with acute coronary syndromes without ST elevation

Eilon Ram  1 , Leonid Sternik  2 , Robert Klempfner  3 , Zaza Iakobishvili  4 , Yael Peled  3 , Nir Shlomo  3 , Ehud Raanani  2
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Free article
Observational Study

Outcomes of different revascularization strategies among patients presenting with acute coronary syndromes without ST elevation

Eilon Ram et al. J Thorac Cardiovasc Surg. 2020 Oct.
Free article

Abstract

Objective: To compare short- and long-term outcomes of patients hospitalized with non-ST-segment myocardial infarction (NSTEMI) or unstable angina (UA) who were referred for revascularization by either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) in a real-world national cohort.

Methods: This observational study included 5112 patients, who underwent either CABG or PCI, admitted for NSTEMI or UA and were enrolled in the Acute Coronary Syndrome Israeli Survey between 2000 and 2016. Propensity score-matching analysis compared early outcomes and all-cause mortality in patients who underwent revascularization by PCI with revascularization by CABG.

Results: Of the 5112 patients, 4327 (85%) underwent PCI and 785 (15%) CABG. Following propensity score analysis, 447 pairs were chosen (1:1). Independent predictors for CABG referral included 3-vessel CAD (odds ratio [OR], 5.5; 95% confidence interval [CI], 4.5-6.7, P < .001), absence of on-site cardiac surgery (OR, 1.3; 95% CI, 1.1-1.6, P = .004), no previous PCI (OR, 1.5; 95% CI, 1.2-1.9, P = .002) and no previous myocardial infarction (OR, 1.3; 95% CI, 1-1.7, P = .022). The 10-year mortality risk was significantly lower among those who underwent CABG compared with PCI (20.4% vs 28.4%, P = .006). Consistent with these findings, multivariable analysis showed that referral to CABG was independently associated with a significant 65% reduction in the risk of 10-year mortality (P < .001). This long-term advantage was seen among male patients (P < .001) and not female patients (P = .910).

Conclusions: In a real-life setting, revascularization by CABG provides excellent long-term outcomes in patients with NSTEMI or UA. The advantage of CABG over PCI was seen only in male patients.

Keywords: acute coronary syndromes; coronary artery bypass grafting; coronary artery disease; percutaneous coronary intervention; revascularization.

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