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Review
. 2019 Sep 26;11(9):634-649.
doi: 10.4252/wjsc.v11.i9.634.

Using induced pluripotent stem cells for modeling Parkinson's disease

Minjing Ke  1 , Cheong-Meng Chong  1 , Huanxing Su  2
Affiliations
Review

Using induced pluripotent stem cells for modeling Parkinson's disease

Minjing Ke et al. World J Stem Cells. .

Abstract

Parkinson's disease (PD) is an age-related neurodegenerative disease caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. As DA neurons degenerate, PD patients gradually lose their ability of movement. To date no effective therapies are available for the treatment of PD and its pathogenesis remains unknown. Experimental models that appropriately mimic the development of PD are certainly needed for gaining mechanistic insights into PD pathogenesis and identifying new therapeutic targets. Human induced pluripotent stem cells (iPSCs) could provide a promising model for fundamental research and drug screening. In this review, we summarize various iPSCs-based PD models either derived from PD patients through reprogramming technology or established by gene-editing technology, and the promising application of iPSC-based PD models for mechanistic studies and drug testing.

Keywords: Aging; Dopaminergic neurons; Induced pluripotent stem cells; Parkinson’s disease; Somatic cell reprogramming.

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Conflict of interest statement

Conflict-of-interest statement: The authors have declared no conflicts of interest.

Figures

Figure 1
Figure 1
Potential applications of induced pluripotent stem cells for study of Parkinson’s disease. Somatic cells are extracted from either normal individuals or patients and then reprogrammed to induced pluripotent stem cells (iPSCs). Gene editing technology enables one to generate knockin mutant Parkinson’s disease (PD) iPSCs and isogenic control cell lines. Dopamine (DA) neurons can be successfully differentiated from iPSCs. Both patient-derived and gene-editing iPSCs could be powerful tools for modeling PD for mechanistic studies and drug discovery. Healthy or corrected iPSCs could serve as normal controls and cell sources for cell therapy. iPSCs: Induced pluripotent stem cells; DA: Dopaminergic.
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