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Review
. 2019 Oct;71(10):1053-1060.
doi: 10.11477/mf.1416201404.

[Apolipoprotein E4, a Genetic Risk Factor for Alzheimer's Disease]

[Article in Japanese]
Masataka Kikuchi  1 , Akihiro Nakaya
Affiliations
Review

[Apolipoprotein E4, a Genetic Risk Factor for Alzheimer's Disease]

[Article in Japanese]
Masataka Kikuchi et al. Brain Nerve. 2019 Oct.

Abstract

Apolipoprotein E (APOE) is reported to be a strong genetic risk factor for Alzheimer's disease (AD), broadly contributing to the AD pathologies observed in most populations. However, it is difficult to explicate these AD pathologies based only on the known functions of APOE. In this review article, we revisited the histories and functions of APOE and also reviewed its recently elucidated the pleiotropic roles in the brain.

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