Photodynamic Therapy: A Brief History

doi:10.3390/jcm8101581

Review

. 2019 Oct 2;8(10):1581.

doi: 10.3390/jcm8101581.

Photodynamic Therapy: A Brief History

David Kessel¹

Affiliations

PMID: 31581613
PMCID: PMC6832404
DOI: 10.3390/jcm8101581

Review

Photodynamic Therapy: A Brief History

David Kessel. J Clin Med. 2019.

. 2019 Oct 2;8(10):1581.

doi: 10.3390/jcm8101581.

Author

David Kessel¹

Affiliation

¹ Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA. dhkessel@med.wayne.edu.

PMID: 31581613
PMCID: PMC6832404
DOI: 10.3390/jcm8101581

Abstract

Photodynamic therapy (PDT) involves the selective sensitization of tissues to light. A major advance in the field occurred when Thomas Dougherty at the Roswell Park Cancer Institute initiated a series of clinical studies that eventually led to FDA approval of the procedure. This report contains a summary of Dougherty's contributions and an assessment of where this has led, along with a summary of implications for future drug development.

Keywords: dougherty; hematoporphyrin derivative; photodynamic therapy; photofrin.

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Conflict of interest statement

The author declares no conflict of interest.

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References

1. Raab O. Uber die Wirkung, fluorescirender Stoffe auf infusorien. Z. Biol. 1900;39:524–546.
1. von Tappeiner H., Jodlbauer A. Über die Wirkung der photodynamischen (fluorescierenden) Stoffe auf Protozoen und Enzyme. Dtsch. Arch. Klin. Med. 1904;39:427–487.
1. Figge F.H.J., Weiland G.S., Nanganiello L.O.J. Cancer detection and therapy. Affinity of neoplastic, embryonic, and traumatized tissues for porphyrins and metalloporphyrins. Proc. Soc. Exp. Biol. Med. 1948;68:640–641. doi: 10.3181/00379727-68-16580. - DOI - PubMed
1. Rasmussen-Taxdal D.S., Ward G.E., Figge F.H.J. Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin. Cancer. 1955;8:78–81. doi: 10.1002/1097-0142(1955)8:1<78::AID-CNCR2820080109>3.0.CO;2-L. - DOI - PubMed
1. Lipson R.L., Baldes E.J., Olsen A.M. Hematoporphyrin derivative: A new aid for endoscopic detection of malignant disease. J. Thorac. Cardiovasc. Surg. 1961;42:623–629. - PubMed

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[1] Raab O. Uber die Wirkung, fluorescirender Stoffe auf infusorien. Z. Biol. 1900;39:524–546.

[2] Raab O. Uber die Wirkung, fluorescirender Stoffe auf infusorien. Z. Biol. 1900;39:524–546.

[3] von Tappeiner H., Jodlbauer A. Über die Wirkung der photodynamischen (fluorescierenden) Stoffe auf Protozoen und Enzyme. Dtsch. Arch. Klin. Med. 1904;39:427–487.

[4] von Tappeiner H., Jodlbauer A. Über die Wirkung der photodynamischen (fluorescierenden) Stoffe auf Protozoen und Enzyme. Dtsch. Arch. Klin. Med. 1904;39:427–487.

[5] Figge F.H.J., Weiland G.S., Nanganiello L.O.J. Cancer detection and therapy. Affinity of neoplastic, embryonic, and traumatized tissues for porphyrins and metalloporphyrins. Proc. Soc. Exp. Biol. Med. 1948;68:640–641. doi: 10.3181/00379727-68-16580. - DOI - PubMed

[6] Figge F.H.J., Weiland G.S., Nanganiello L.O.J. Cancer detection and therapy. Affinity of neoplastic, embryonic, and traumatized tissues for porphyrins and metalloporphyrins. Proc. Soc. Exp. Biol. Med. 1948;68:640–641. doi: 10.3181/00379727-68-16580. - DOI - PubMed

[7] Rasmussen-Taxdal D.S., Ward G.E., Figge F.H.J. Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin. Cancer. 1955;8:78–81. doi: 10.1002/1097-0142(1955)8:1<78::AID-CNCR2820080109>3.0.CO;2-L. - DOI - PubMed

[8] Rasmussen-Taxdal D.S., Ward G.E., Figge F.H.J. Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin. Cancer. 1955;8:78–81. doi: 10.1002/1097-0142(1955)8:1<78::AID-CNCR2820080109>3.0.CO;2-L. - DOI - PubMed

[9] Lipson R.L., Baldes E.J., Olsen A.M. Hematoporphyrin derivative: A new aid for endoscopic detection of malignant disease. J. Thorac. Cardiovasc. Surg. 1961;42:623–629. - PubMed

[10] Lipson R.L., Baldes E.J., Olsen A.M. Hematoporphyrin derivative: A new aid for endoscopic detection of malignant disease. J. Thorac. Cardiovasc. Surg. 1961;42:623–629. - PubMed

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Photodynamic Therapy: A Brief History

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Photodynamic Therapy: A Brief History

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