Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family

doi:10.3390/vaccines7040123

Review

. 2019 Sep 20;7(4):123.

doi: 10.3390/vaccines7040123.

Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family

Shu Hui Wong^{1

2}, Alagie Jassey³, Jonathan Y Wang⁴, Wei-Cheng Wang⁵, Ching-Hsuan Liu^{6

7}, Liang-Tzung Lin^{8

9}

Affiliations

¹ International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m142107001@tmu.edu.tw.
² Institut de Recherches Cliniques de Montréal, Montreal, QC H2W 1R7, Canada. m142107001@tmu.edu.tw.
³ International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. d142105007@tmu.edu.tw.
⁴ International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m142107002@tmu.edu.tw.
⁵ Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m120107011@tmu.edu.tw.
⁶ Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. d119107007@tmu.edu.tw.
⁷ Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada. d119107007@tmu.edu.tw.
⁸ Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. ltlin@tmu.edu.tw.
⁹ Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. ltlin@tmu.edu.tw.

PMID: 31547131
PMCID: PMC6963367
DOI: 10.3390/vaccines7040123

Review

Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family

Shu Hui Wong et al. Vaccines (Basel). 2019.

. 2019 Sep 20;7(4):123.

doi: 10.3390/vaccines7040123.

Authors

Shu Hui Wong^{1

2}, Alagie Jassey³, Jonathan Y Wang⁴, Wei-Cheng Wang⁵, Ching-Hsuan Liu^{6

7}, Liang-Tzung Lin^{8

9}

Affiliations

¹ International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m142107001@tmu.edu.tw.
² Institut de Recherches Cliniques de Montréal, Montreal, QC H2W 1R7, Canada. m142107001@tmu.edu.tw.
³ International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. d142105007@tmu.edu.tw.
⁴ International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m142107002@tmu.edu.tw.
⁵ Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. m120107011@tmu.edu.tw.
⁶ Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. d119107007@tmu.edu.tw.
⁷ Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada. d119107007@tmu.edu.tw.
⁸ Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. ltlin@tmu.edu.tw.
⁹ Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan. ltlin@tmu.edu.tw.

PMID: 31547131
PMCID: PMC6963367
DOI: 10.3390/vaccines7040123

Abstract

Viruses in the Flaviviridae family are important human and animal pathogens that impose serious threats to global public health. This family of viruses includes emerging and re-emerging viruses, most of which are transmitted by infected mosquito or tick bites. Currently, there is no protective vaccine or effective antiviral treatment against the majority of these viruses, and due to their growing spread, several strategies have been employed to manufacture prophylactic vaccines against these infectious agents including virus-like particle (VLP) subunit vaccines. VLPs are genomeless viral particles that resemble authentic viruses and contain critical repetitive conformational structures on their surface that can trigger the induction of both humoral and cellular responses, making them safe and ideal vaccine candidates against these viruses. In this review, we focus on the potential of the VLP platform in the current vaccine development against the medically important viruses in the Flaviviridae family.

Keywords: Flaviviridae; immunogenicity; vaccines; virus-like particles.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

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1. Fatmi S.S., Zehra R., Carpenter D.O. Powassan virus—A new reemerging tick-borne disease. Front. Public Health. 2017;5:342. doi: 10.3389/fpubh.2017.00342. - DOI - PMC - PubMed
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1. Chevaliez S., Pawlotsky J.-M. HCV genome and life cycle. Hepat. C Viruses Genomes Mol. Biol. 2006;1:5–47. - PubMed
1. Ishikawa T., Yamanaka A., Konishi E. A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available. Vaccine. 2014;32:1326–1337. doi: 10.1016/j.vaccine.2014.01.040. - DOI - PubMed

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[1] Lindenbach B.D., Murray C.L., Thiel H., Rice C.M. Flaviviridae. In: Knipe D.M., Howley P.M., editors. Fields Virology. 6th ed. Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2013.

[2] Lindenbach B.D., Murray C.L., Thiel H., Rice C.M. Flaviviridae. In: Knipe D.M., Howley P.M., editors. Fields Virology. 6th ed. Lippincott Williams & Wilkins; Philadelphia, PA, USA: 2013.

[3] Fatmi S.S., Zehra R., Carpenter D.O. Powassan virus—A new reemerging tick-borne disease. Front. Public Health. 2017;5:342. doi: 10.3389/fpubh.2017.00342. - DOI - PMC - PubMed

[4] Fatmi S.S., Zehra R., Carpenter D.O. Powassan virus—A new reemerging tick-borne disease. Front. Public Health. 2017;5:342. doi: 10.3389/fpubh.2017.00342. - DOI - PMC - PubMed

[5] Collins M.H., Metz S.W. Progress and Works in Progress: Update on Flavivirus Vaccine Development. Clin. Ther. 2017;39:1519–1536. doi: 10.1016/j.clinthera.2017.07.001. - DOI - PubMed

[6] Collins M.H., Metz S.W. Progress and Works in Progress: Update on Flavivirus Vaccine Development. Clin. Ther. 2017;39:1519–1536. doi: 10.1016/j.clinthera.2017.07.001. - DOI - PubMed

[7] Chevaliez S., Pawlotsky J.-M. HCV genome and life cycle. Hepat. C Viruses Genomes Mol. Biol. 2006;1:5–47. - PubMed

[8] Chevaliez S., Pawlotsky J.-M. HCV genome and life cycle. Hepat. C Viruses Genomes Mol. Biol. 2006;1:5–47. - PubMed

[9] Ishikawa T., Yamanaka A., Konishi E. A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available. Vaccine. 2014;32:1326–1337. doi: 10.1016/j.vaccine.2014.01.040. - DOI - PubMed

[10] Ishikawa T., Yamanaka A., Konishi E. A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available. Vaccine. 2014;32:1326–1337. doi: 10.1016/j.vaccine.2014.01.040. - DOI - PubMed

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Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family

Affiliations

Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family

Authors

Affiliations

Abstract

Conflict of interest statement

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References

Publication types

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LinkOut - more resources

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